Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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The pedigree below shows the inheritance pattern of a rare X-linked allele for one family. The filled in circles and squares show affected individuals. Circles represent females and squares represent males. What is the probability of individual III-2 being born male and affected? Please explain your answer.
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- The pedigree chart provided below traces the occurrence of a disease through the generations of a family. Determine what type of inheritance pattern this disease has.arrow_forwardHemophilia, disease in which the blood lacks a clotting factor, is caused by an X linked recessive gene. Joe doe not have hemophilia and Lucille is heterozygous for the condition. What is the chance that their MALE child will have hemophilia? (Note: you are calculating the probability for their MALE children only, in other words if they have 1 male child, what is the probability that he will be born with the disease?) 0% 1/4 or 25% 2/4 or 50% 3/4 or 75% 4/4 or 100%arrow_forwardShown below is a pedigree for a completely penetrant trait called Adams syndrome in which babies are born blind. This trait occurs when an allele of the adams gene is associated with ≥200 tandem trinucleotide repeats (the normal number is 10). First cousins, III-1 and III-2 married and their first child (IV-1) was blind. For their next child, they decided to do in vitro fertilization with III-1's sperm and III-2's eggs to generate six embryos (labeled E1-6). When each embryo contained eight cells, a single cell was removed and genomic DNA was isolated. PCR reactions using primers that flank the trinucleotide repeat region were then performed and the resulting fragments were fractionated on an agarose gel. PCR reactions using genomic DNA from III-1, III-2 and IV-1 were included as controls. The DNA was visualized using a fluorescent dye and the gel is shown below. Based on this information, select the best answer from the list to the questions below. || E1 = embryo 1 IV E1 E2 E3 E4 E5…arrow_forward
- The pedigree below shows a family affected by a disease. Assume that the individuals marked with an asterisk (*) do not carry any allele associated with the affected phenotype, no other mutation spontaneously occurred, and complete penetrance. Answer the following questions below. Use the notation XR for the allele associated with the dominant phenotype and Xr for the allele associated with the recessive phenotype. Q1) Give the genotypes for as many individuals in the pedigree as possible.arrow_forwardThe following pedigree is of an X-linked dominant trait. What is the magnitude of penetrance for this trait in the pedigree? 01 0.29 O 0.5 O 0.71arrow_forwardWhat is the approximate percentage chance that individual V.2, shown in the pedigree diagram below will have inherited the X- linked recessive allele shown to be carried by his great-great-grandmother? Note: only type the number, not the percentage symbol. Answer: The chance that individual V.2 shown in the pedigree below has inherited the X-linked recessive allele shown to be carried by his great-great grandmother is approximately Blank 1 percent. 노 ㅍ먹이 12 I 마일 메인 de 먹어 요 58 ㅁ + ܡܐarrow_forward
- Duchenne’s muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness and is often fatal. “XD” represents the wild type allele, and “Xd,” the mutant allele. Jonah is XDXd Y and his brother Pete is Xd Y. Jonah and Pete BOTH have DMD of equal severity and phenotypes. You might have thought Jonah’s DMD would be less severe given his genotype. To better understand the situation, you investigate Jonah’s Xist chromosome region in his defective muscle cells. Which of the following is consistent with his phenotype? (Select all that apply.) The Xd-containing chromosome is inactive in defective muscle cells. The XD-containing chromosome has a methylated Xist promoter. The XD-containing chromosome has an unmethylated Xist promoter. The Xd-containing chromosome is active in defective muscle cells.arrow_forwardO All three genes are linked, but need to do more crosses and data to determine the gene order. All three genes are linked with the flower color gene (F) in the middle. All three genes are linked with the seed weight gene (S) in the middle. All three genes are linked with the leaf size gene (L) in the middle.arrow_forwardThe images attached show a parental cross that is homozygous wild female x white male. F1 were intercrossed to produce the F2 generation as indicated below: Wild Female: 416 Wild Male: 192 White Female: 0 White Male: 192 A chi-square analysis was done and an image was also attached. Please discus what conclusions can be made based on the data/findings. What inheritance pattern is this?arrow_forward
- In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected || IV V 5600 orize 077808 15 10 9 10 CHO વ Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk.…arrow_forward3) You have sought a job at a human genetic counseling clinic. They gave you an aptitude test shown below. Answer the yes/no questions concerning each of the following pedigrees. Pedigree A: YES or NO Could this trait be inherited as a simple autosomal recessive? Could this trait be inherited as a simple autosomal dominant? Could this trait be inherited as a simple X-linked recessive? Could this trait be inherited as a simple X-linked dominant? Pedigree B: YES or NO Could this trait be inherited as a simple autosomal recessive? Could this trait be inherited as a simple autosomal dominant? Could this trait be inherited as a simple X-linked recessive? Could this trait be inherited as a simple X-linked dominant?arrow_forwardPlease consider the pedigree below. There are no cases of false paternity. AB 2 I II 2 3 A (AB A)B 1 III 2 3 4 IV B 1 2 a. Which individual/s definitely has/have Bombay phenotype in this extended family? b. What are the genotypes of individuals II-2 and II-3 at the ABO and H loci?arrow_forward
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