The pedigree chart provided below traces the occurrence of a disease through the generations of a family. Determine what type of inheritance pattern this disease has.

Given the pedigree below, answer the following questions. Note that filled symbols represent affected individuals. You assume that the allele carrying the disease is rare and therefore individuals marrying into the family are unlikely to have defective alleles. Also, assume complete penetrance. Q2) What are the genotypes of the following individuals listed in the table below? Use the uppercase “A” to represent the dominant allele and lowercase “a” for the recessive allele. Individual Genotype II-7   III-5   IV-1   IV-3   I-2   III-7

Below is a pedigree chart for a family that has a history of Alkaptonuria.   Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications.  Given this pedigree answer the following questions.   Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3?  If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype?  Why or why not?

Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. For epilepsy, the concordance values are 72% for monozygotic twins and 15% for dizygotic twins. 1) Is this a single gene inheritance or multifactorial disease? 2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.

Sickle cell anemia is a genetic disease that causes red blood cells to form incorrectly, slowing the movement of blood and causing tissue damage. A person can be homozvgous dominant for normal blood cell shape, heterozygous or homozygous for sickle cells. Using this information and the figure below, determine the type of inheritance pattern that the sickle cell disorder follows.

Please do the pedigree in the attached picture

Determine what is the most likely mode of inheritance of this disease (whether it is inherited as the result of an X-linked dominant or X-linked recessive trait). Use "A" for the allele associated with the dominant phenotype, and lowercase "a"" for the allele associated with the recessive phenotype. Write the most probable genotype for each individual based on the mode of inheritance you have determined. Show how all the partners are crossed and the expected offspring produced (You may use Punnett Square). OT I OT do II

Choose a pattern of inheritance (autosomal recessive, X-linked dominant, etc.) and identify a disorder with that inheritance pattern. Explain how using a pedigree will help a family understand their probability of passing or inheriting the disorder.

The following pedigree illustrates the inheritance of Tay-Sachs disease in four generations of a family. Interpret the pedigree and determine whether the trait is dominant or recessive. What happened in the third generation?

Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…