Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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The individuals with a certain disease are shown in this pedigree. The disease is caused by an autosomal recessive allele, q. Give the genotype of the following individuals:
(a) III-1 (the girl at lower left corner)
(b) II-1 (the girl’s mother)
(c) II-2 (the girl’s father)
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- For each of the listed modes of single gene inheritance (assuming complete penetrance), indicate whether it is POSSIBLE or IMPOSSIBLE, given this pedigree. nс Autosomal recessive 11 [Select] Autosomal dominant [Select] Autosomal recessive, sex-limited to males [Select] Autosomal dominant, sex-limited to males [Select] 13 Autosomal recessive, sex-limited to females [Select] Autosomal dominant, sex-limited to females [Select] Autosomal, sex-influenced, dominant in males [Select] Autosomal, sex-influenced, dominant in females [Select] X-linked recessive [Select] Y-linked [Select] X-linked dominant [Select] X-linked recessive, sex-limited to females [Select] X-linked dominant, sex-limited to females [Select] X-linked, sex-limited to males [Select] X-linked, sex-influenced, dominant in females [Select] X-linked, sex-influenced, recessive in females [Select]arrow_forwardPLEASE ANSWER PART C.arrow_forwardThis pedigree traces the inheritance of a rare disease in humans. a. Based on this pedigree, is the allele for this disease dominant or recessive? Explain. b. What genotypes are possible for the individuals labeled 1, 2, and 3?arrow_forward
- John and Sue are expecting a child, but are concerned about a rare autosomal recessive disease that is present in both of their families. In the pedigree, John is represented as individual III-11 and Sue is represented as individual III-12; both are unaffected. John's sister, III-10, and Sue's brother, III-13, both do not show evidence of the disease, but John's paternal grandmother and Sue's maternal grandfather both had the disease. Assign the appropriate symbol to each individual in the pedigree. I 3 4. Answer Bank II III 11 12 13 10 2.arrow_forwardThe attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1arrow_forwardDefine the pedigree symbol(s) associated with each of the following individuals. Please be as specific as possible. Be sure to indicate WHOSE pedigree symbols you are defining. (i) II-1 and II-3 (ii) II-5 (iii) II-9-10 (iv) II-11 (v) IV-14 and IV-15 (vi) IV-18arrow_forward
- *Cystic fibrosis is a rare autosomal recessive condition. phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family.² a) Draw the pedigree as far as described. b) If the frequency of heterozygotes in the general population is 1/50, what is the probability that the couple's first child will have cystic fibrosis? c) If the first child does have cystic fibrosis, what is the probability that the second child will be normal?arrow_forwardBelow is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forwardThe pedigree below represents a family in which some members (shaded) have a monogenic genetic disease. Assume it is fully penetrant. 4999 a. If the disease were X-linked recessive, what would be the probability that a male child born to II- 3 and II-4 will be affected? Why? (Note: we already know the child is male.) b. If the disease were autosomal dominant what would be the probability that a male child born to II-3 and II-4 will be affected? Why? (Note: we already know the child is male.)arrow_forward
- Pedigree attached shows an autosomal recessive genetic disease. G is the normal allele and g is the disease-causing allele. Individual 1’s father is heterozygous (*) and his mother is homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual’s phenotype with regard to the disease. part a) What is the probability that individuals 1 and 2 will have a child (5) who is a boy with the disease (the child is unborn and the sex is not yet known)? a)1/8 b)1/4 c)0 d)1/16 part b) What is the probability that the daughter (6) that individual 3 and 4 just had will have the disease? a)1/8 b)1/6 c)1/4 d)1/12arrow_forwardYour brother has an autosomal recessive disorder, while you are unaffected. Neither one of your parents is affected. Explain how this is possible.arrow_forward49arrow_forward
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