Targeted delivery of a "death package" 1 MHC class I 2 3 Virus molęcule Viral genome -Natural killer cell Virus infects a cell. Virus prevents its host cell from displaying MHC class I molecules. Without these, the cell cannot be a target of Tc cells. Natural killer (NK) cell initiates apoptosis in the stressed "self" cell that lacks MHC class I molecules. Infected cell undergoes apoptosis. FIGURE 15.23 Natural Killer (NK) Cells Destroy Stressed "Self" Cells That Lack MHC Class I Molecules

Principles Of Pharmacology Med Assist
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Chapter16: Antifungal, Antiviral, And Immunizing Agents
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Why would a virus that can interfere with a host cell’s production of MHC class I molecules be at an advantage?

Targeted delivery
of a "death package"
1
MHC class I
2
3
Virus
molęcule
Viral genome
-Natural
killer cell
Virus infects a cell.
Virus prevents its host cell
from displaying MHC class I
molecules. Without these,
the cell cannot be a target
of Tc cells.
Natural killer (NK) cell
initiates apoptosis in the
stressed "self" cell that
lacks MHC class I molecules.
Infected cell
undergoes apoptosis.
FIGURE 15.23 Natural Killer (NK) Cells Destroy Stressed "Self" Cells That Lack MHC Class I Molecules
Transcribed Image Text:Targeted delivery of a "death package" 1 MHC class I 2 3 Virus molęcule Viral genome -Natural killer cell Virus infects a cell. Virus prevents its host cell from displaying MHC class I molecules. Without these, the cell cannot be a target of Tc cells. Natural killer (NK) cell initiates apoptosis in the stressed "self" cell that lacks MHC class I molecules. Infected cell undergoes apoptosis. FIGURE 15.23 Natural Killer (NK) Cells Destroy Stressed "Self" Cells That Lack MHC Class I Molecules
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