Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM:
- MHC class II molecules traffic to the cell surface with CLIP in their binding sites.
- No MHC class II molecules are released to traffic to the cell surface.
- MHC class II molecules bind to HLA-DO and are inhibited from binding peptides.
- Pathogens can evade the immune system by blocking peptide exchange on MHC class II.
- HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.
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