Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM:MHC class II molecules traffic to the cell surface with CLIP in their binding sites.No MHC class II molecules are released to traffic to the cell surface.MHC class II molecules bind to HLA-DO and are inhibited from binding peptides.Pathogens can evade the immune system by blocking peptide exchange on MHC class II.HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.

The major histocompatibility complex (MHC) class II is and the associated peptides are obtained from…

Answered: an important component of antigen…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM:

MHC class II molecules traffic to the cell surface with CLIP in their binding sites.
No MHC class II molecules are released to traffic to the cell surface.
MHC class II molecules bind to HLA-DO and are inhibited from binding peptides.
Pathogens can evade the immune system by blocking peptide exchange on MHC class II.
HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.

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