Alpha Betachain chainCHOCHODisulfide bridgeCHOCHOWhat kind of receptor is show in the figure?T-cell receptorimpossible to tellB-cell receptorVariable region "V"Constant region "C"Hinge "HTransmembrane regionCytoplasmic tail

It is an T cell receptor Explanation:The T cell receptor (TCR) is a crucial component of the immune…

Answered: Alpha Beta chain chain CHO CHO…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 6RE

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The white blood cells known as T lymphocytes respond to antigens thatbind specifi cally to the T cell receptor, which consists of an antigen-binding αβ transmembrane protein as well as a set of transmembrane signaltransducing proteins known as CD3 that are targets of NRTKs. Thecytoplasmic domains of the CD3 proteins are positively charged and, in the absence of antigen, interact with the intracellular surface of the plasma membrane in such a way that buries several of their Tyr residues in the lipidbilayer. Antigen binding to the T cell receptor leads to a localized infl ux ofCa2+ ions. (a) Explain how a high concentration of Ca2+ could promote phosphorylation and activation of the CD3 proteins. (b) Would this henomenon make the T lymphocyte more or less responsive to the antigen?
Activation of which of the following do not cause phagocytosis to occur O Pattern Recognition Receptors O Fc Receptors O B-Cell Receptor T-Cell Receptor
Innate lymphoid cells (ILCS) , implicated in tissue repair and maintenance of barrier integrity, are present in large numbers in the intestine which is also innervated by intestinal nervous system (ENS). Reccent research has shown that ILCS- express receptors for IgG express receptors for neuropeptides and neurotransmitters O function through pattern recognition receptors (PRRS) such as TLRS
For many years it was a complete mystery howcytotoxic T cells could see a viral protein that seemed to bepresent only in the nucleus of the virus-infected cell. Theanswer was revealed in a classic paper that took advan-tage of a clone of T cells whose T cell receptor was directedagainst an antigen assoicated with the nuclear protein ofthe 1968 strain of influenza virus. The authors of the paperfound that when they incubated high concentrations ofcertain peptides derived from the viral nuclear protein, thecells became sensitive to lysis by subsequent incubationwith the cytotoxic T cells. Using various peptides from the1968 strain and the 1934 strain (with which the cytotoxic Tcells did not react), the authors defined the particular pep-tide responsible for the T cell response (Figure Q24–1).A. Which part of the viral protein gives rise to thepeptide that is recognized by the clone of cytotoxic T cells? Why do not all viral peptides sensitize the target cells forlysis by the cytotoxic T…
On phagocytes and other cells, (?????) are receptors classified as part of the innate immune system that detect molecular motifs not usually found in humans, such as double stranded RNA or lipopolysaccharide and trigger an immune response.
Gram negative cell walls contain lipopolysaccharide (LPS) as a unique component. All of the following apply to LPS EXCEPT O LPS is composed of mycolic acids that protect the cell from phagocytosis LPS is a PAMP that can be recognized by toll-like receptors (TLRS) as a foreign molecule fo rphagocytosis O LPS can be a target for specific IgG for ADCC-opsonization LPS can be recognized by B cells in the aosence of MHC molecules All of the answers apply, no exception O LPS is found in the outer membrane of Gram negative cells
Which of these best describes NOD-like receptors? Most are found on the plasma membrane where they recognize external components of pathogens. They are cytosolic proteins activated by intracellular PAMPS and DAMPS. They bind double-stranded nucleic acids of viruses. They are found only on the plasma membranes of T and B lymphocytes. O O O O
Which of the flollowing reasons DOES NOT account for the barrier protective effect of IL-22? Students, this question was not on your reading, but you should be able to answer correctly. O stimulates cell survival and prliferation O stimulates synthesis of antimicrobilas like defensins etc prevents neuro-immune cross tqalk takes effect on stromal and epithelial cells
There are several important mechanisms for generating diversity in immunoglobulin and T cell receptors. Explain the similarities and differences in mechanisms that generates diversity in these receptors.
"Gamma-delta' T cells differ from 'alpha-beta' T cells by all of the following except O alpha-beta cells are more commonly found in skin and other tissues, while gamma-delta cells are primarily in lymph nodes. gamma-delta cells undergo more hypermutation for their receptor genes. gamma-delta cells respond more with non-peptide antigens, especially phospholipids. O production of an effector response occurs more rapidly in alpha-beta T cells.
T cells reach the central nervous system by way of- action of membrane pore-forming proteases migrating macrophages choroid plexus and meninges
T-cell receptors concentrate diversity in the third hypervariable region. For alpha:beta T-cell receptors, sequence diversity is heavily concentrated at the junctions formed by the rearrangement of gene segments during the generation of the expressed Va and Vb regions. The result of this organization is to position the most variable part of the T-cell receptor over a certain region of the ligand recognized by this receptor. Which region (outlined in red in figure below) indicates this part of the ligand recognized by the T-cell receptor?

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