Match the term with its correct description Long, flexible molecule expressed on B-cells, macrophages and FDC which binds to C3d B-cell co-receptor Cognate pair Rapidly dividing cell which is going through somatic hypermutation Slowly dividing cell which searches for antigen match on FDC ✓ Choose... CR2 Centrocyte CR2, CD19, CD81 TFH cell and B-cell which recognize same antigen Centroblast Choose... Choose... ++ ➡

Match the term with its correct description Long, flexible molecule expressed on B-cells, macrophages and FDC which binds to C3d B-cell co-receptor Cognate pair Rapidly dividing cell which is going through somatic hypermutation Slowly dividing cell which searches for antigen match on FDC ✓ Choose... CR2 Centrocyte CR2, CD19, CD81 TFH cell and B-cell which recognize same antigen Centroblast Choose... Choose... ++ ➡

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section12.4: B Lymphocytes: Antibody-mediated Immunity

Problem 3CYU

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This immune cell is able to respond quickly after any subsequent encounter with the samo antigen Oa antigen presenting cell O b. memory cell neutrophil Od. planma cell QUESTION 19 The following events occur during a T-dependent humoral imeune response. Put them in the conect order U CD, cell along with T coll receptor recognizes he antigen on the APC and forms a complex 2 Planima celin are fomed and startsecreting antbodies 3H coll digents the antigen and displays it complexed with MHC I marke AJ CD. cell diflerentiates into a Thelper cell (Th2) 5E cell phagocytoses an antigen, 6) Th2 secretes cytokines to activate the B celi and undergo cional expansion O1,3, 5, 4. 6. 2 O b.1, 5, 4. 2, 6 3 Oc. 5, 3 4, 1, 2, 6 O d. 5, 3, 1, 4, 6, 2
binds to the alpha 3 domain of MHC Class I positioned in the T-cell receptor a-chain locus between Va and Ja gene segments made up of y, 8 and & components has four extracellular Ig-like domains noncovalently compitxed with the MHC class I alpha chain
Match the antibody isotype with its functional characteristics. Highly effective at activating complement, too large to get to infected tissues Crosses cells, including the placenta, neutralizes toxins Dimeric form crosses the intestinal epithelia using PlgR Crosslinking on the surface of the mast cell leads to degranulation and release of histamine Although the exact function of this isotype is unknown, we know it does NOT fix complement ✓Choose... IgD IgM IgG IgA IgE Choose...
Briefly describe the effector functions of the following subsets of CD4* helper T lymphocytes and distinguish their cytokine profiles: уThi cell ii)Th2 cell
Some Type-II immunopathology mediated autoimmune diseases have manifestations inmultiple different organs. Discuss how antibodies to one single antigen can cause damage inmultiple sites throughout the body. Things you might discuss include, but are not limited towhere the antigen could be expressed, how antibodies are made, how they bind antigen,where they circulate, the ratios of antigen to antibody, mechanisms of the immune systemthat result in cellular/tissue damage, or how immune system components can affect otherorgans. You might also comment on what makes one antigen an attractive target rather thananother. Please do NOT comment on all the things listed above, they are just to get youthinking. If you are having trouble getting started, it might help to think about a specificdisease which affects multiple organs.
Circulation in blood Immunocompetent, but still naive, lymphocyte migrates via blood A B C D E B D Immature lymphocytes D B [Choose ] [Choose ] [Choose ] [Choose ] [Choose ] [Choose ]
Examine Type IV hypersensitivities by completing each sentence. 54 Туре IV МНС I tuberculin Compared to Type III hypersensitivities, reactions primarily involve -cell activity. T allografts Type IV dysfunction is known as secondary antigen exposure. hypersensitivity for symptoms arise 1 to several days following contact dermatitis delayed One example, infectious allergy, occurs during the reaction in persons sensitized by tuberculosis Lysosome infection. xenografts GVHD which occurs after exposure to antigens in The most common delayed allergic reaction, however, is plant resins, drugs, or personal articles, and involves the production of inflammatory cytokines that cause blistering. Autografts В -mediated reactions, while Finally, host rejection of grafted tissue can occur due to occurs when passenger cells in the grafted tissue attack host cells. MHC II Psoriasis
TABLE 6 | Correlation between immune markers and age. Marker NCI PAN LCI LP NK activity (lysis %) R Spearman -0.406 -0.305 -0.239 -0.204 -0.016 Р 0.004 0.035 0.101 0.165 0.913 NCI, Neutrophil Chemotaxis Index; PAN, phagocytic activity of neutrophils; LCI, Lymphocyte Chemotaxis Index; LP, lymphocyte proliferation; NK, natural killer. p is the associated value to the corresponding statistical test.
L T cells and B cells exhibit certain similarities and differences. Check () the appropriate spaces in the table below to indicate the lymphocyte type that exhibits eachcharacteristic. Characteristi cell cell Originates in bone marrow from stem cells called hemocytoblasts Progeny are plasma cells Progeny include suppressors, helpers, and killer cells Progeny include memory cells Is responsible for directly attacking foreign cells or virus-infected cells Produce antibodies that are released to body fluids Bears a cell-surface receptor capable of recognizing a specific antigen Forms clones upon stimulation Accounts for most of the lymphocytes in the circulation
DRAW IT Sketch a B cell antigen receptor. Label the Vand C regions of the light and heavy chains. Label theantigen-binding sites, disulfide bridges, and transmembrane region. Where are these features located relativeto the V and C regions?
Removing functionality from a B cell without killing it is called ________. clonal selection clonal expansion clonal deletion clonal anergy
Determine which statement(s) are true/false NK cells are a type of lymphocyte involved in acquired immunity Plasma cells are a type of B- cell that directly bind antigens on target cells ✓ [Choose ] False True Binding of antigen to the cell surface of B-memory cells is a trigger for the secondary immune response Loss of MHC Class I expression would decrease the effectiveness of cytotoxic T-cell response [Choose ] [Choose ] [Choose ] >