Q) During M-phase of cell cycle, active M-Cdk phosphorylates several target proteins in order to regulate their activities. Identify TWO specific examples of such target proteins that are phosphorylated by active M-Cdk, and explain how each of them affects the cell (i.e. their respective biological significance). i) target protein phosphorylated: _______________________________ Biological Significance: ii) target protein phosphorylated: _______________________________ Biological Significance:

Q) During M-phase of cell cycle, active M-Cdk phosphorylates several target proteins in order to regulate their activities. Identify TWO specific examples of such target proteins that are phosphorylated by active M-Cdk, and explain how each of them affects the cell (i.e. their respective biological significance). i) target protein phosphorylated: _ Biological Significance: ii) target protein phosphorylated: _ Biological Significance:

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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The cell cycle is typically thought of as having four stages. Describe the stages of the cell cycle and identify the mechanism(s) involved in progressing or not progressing through the stages with reference to proteins and signalling processes involved. Please keep brief - 10 sentences/dot points max.
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In typical women of reproductive age, the epithelial cells lining the uterus (the endometrium) die and are shed from the body roughly once every month, in the process of menstruation. The triggers in this process include chemical (hormonal) changes and contraction of the blood vessels in the lining. Cell death may be a result of either apoptosis or necrosis. a. Describe the characteristics of each process (apoptosis and necrosis). b.Develop an argument for classifying the process of menstruation as an example of apoptosis, and then argue for classifying it as necrosis. c.Explain which is correct, and provide the supporting evidence?
Briefly describe the cell cycle, its checkpoints, and the general proteins required to move past each checkpoint. For each cell cycle checkpoint, be sure to describe what the cell is "checking for" and how this "check" occurs, along with the result if the checkpoint cannot be passed. Your answer should also include a description of the structure of MPF, its regulation, and its general targets or functions. Be sure to include any accessory molecules or proteins involved in regulation of MPF, while also describing the process by which MPF is formed and activated. In this answer, you should also choose two proteins involved in the cell cycle, which, if mutated, will cause cancer. Describe these proteins and their normal functions, and then show how a mutation in these proteins will result in cancer.
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Drug A323 inhibits the activity of the cyclin-dependent kinase (CDK) - G1 cyclin complex. Consider possible effects of the drug on the cell cycle of normal and malignant cells. Predict what is likely to happen if the drug is added to the cell types described in A). Motivate your answers and describe the role of cycle-regulatory pathways that are relevant with respect to the action. of drug A323. A) Carcinoma cells in which both allels of the Rb gene carries loss of function mutation.
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