G cyclin is degraded after cell enters S phase. CDK CDK Activated G, cyclin/CDK complex G, checkpolnt CELL CYCLE Mitotic cyclin G, cyclin G, checkpolnt Metaphase checkpolnt CDK Activated mitotic cyclin/CDK complex CDK FIGURE 25.15 Cell-cycle control. Progression through the cell cycle requires the formation of activated cyclinCDK complexes. A cell may produce several different types of cyclin proteins, which are ty pically degraded after the cell has advanced to the next phase. The formation of activated cyclin/CDK complexes is regulated by checkpoint proteins. If these proteins detect DNA damage, they will prevent the formation of activated cyclinCDK complexes. In addition, other checkpoint proteins can detect chromosomes that are incorrectly attached to the spindle apparatus and prevent further pro- gression through metaphase. Note that this is a simplified diagram of the cell cycle of humans. Mitotic cyclin is degraded as cell advances through mitosis.

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