How does the activity of MPF (CDK1) vary throughout the cell cycle? Is this correlated with concentration of cyclins? How does cyclin concentration affect MPF activity?

Cyclin-dependent kinases are a type of "microchip" protein that require multiple inputs (i.e., structural alterations) to be activated-- and thus are active only under specific conditions (as shown in the diagram below). How does limiting activity to when all conditions have been met help the cell function properly? INPUTS has this phosphate been removed? been added? has this is cyclin present? phosphate

If p63 can bind to the same promoter elements as p53, why would it be considered an inhibitor of p53?  Can you clarify this relationship a bit?

How are tissue-specific transcription factors regulated? Identify three different ways