How does the activity of MPF (CDK1) vary throughout the cell cycle? Is this correlated with concentration of cyclins? How does cyclin concentration affect MPF activity?

Q: What inhibit CDK activity by bindingdirectly to the cyclin-CDK complex.

A: A cyclin-dependent kinase complex or CDKC or cyclin-CDK is formed by the interaction of a regulatory…

Q: chaperone mediated autophagy.

A: Autophagy that is mediated by chaperone proteins is called chaperone-mediated autophagy. The…

Q: With regards to the colchicine treated garlic root tip, why would you be more likely to see cells in…

A: Introduction : Colchicine is an alkaloid that comes from the plant Colchicum autumnale, which is…

Q: What is a structure in the centromere region of each chromatid that is specialized for conveyance?

A: Cell is the smallest structural and, functional unit of life. It is simple machinery that houses all…

Q: a. chromosomes strongly bound to kinetochore microtubules, ven when not yet bivalently attached o.…

A: The chromosomes move to the opposite poles of the spindle at the stage of anaphase. It is studied…

Q: What three molecular mechanisms alter chromatin structure and are responsible for many epigenetic…

A: Step 1-  A gene is the essential physical and useful unit of heredity. Genes are comprised of DNA…

Q: What is cyclin-CDK complexes

A: Cell cycle regulation is important without cues to grow or to stop growing. Cells would either…

Q: Once cells pass through the restriction point, they are committed to replicate DNA and enter the S…

A: The limitation (R) point has been named the point at G1 at which commitment occurs and the cell no…

Q: Why doesn't Cdk1 active immediately upon binding to cyclin B? What other components of the cell’s…

A: It includes cell division, replication and growth. All these processes should be carried out in a…

Q: Why is G1 a crucial time in the life of a cell?

A: G1 or gap 1 phase is the first phase of interphase or resting phase in the cell cycle.

Q: Where are DNase I hypersensitivity sites found, and what do they indicate about the nature of…

A: Deoxy ribonucleic acid (DNA) is the genetic material of most organisms that carry coded genetic…

Q: in a fat cell what is the result of activation of genes by PPAR gamma/activator proteins binding?…

A: Peroxisome proliferator - activated receptor(PPAR) gamma is a  nuclear receptor of subfamily 1,group…

Q: APC is a ubiquitin ligase activated by M-cyclin Cdk What is the function of APC when bound to…

A: An integral regulator of cell division that is encoded by the CDC20 gene in humans is the cell…

Q: Define about Several types of cellular stress events bring about rapidincreases in the nuclear…

A: The p53 is also known as the guardian of the genome. It is a tumor suppressor gene. The function of…

Q: A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies…

A: A gene that produces a protein that is essential for regulating cell division and death and is…

Q: GAP protien mutation from Arg 789 to alanine constituvely activate the MAPK pathway by preventing…

A: Cell growth and cell division are essential for the development of an organism. A cell before any…

Q: Define Explain the role of CDK inhibitors. If cyclin-CDK com-plexes are necessary to allow regulated…

A: The cell cycle is an important process occurring in a living cell which is consists of four main…

Q: What protein complexes that are related to cohes-ins, facilitate chromosome condensation and are…

A: The study of chemical reactions that occurs within living organisms is called biochemistry. This…

Q: Explain the use of cyclins and cyclin-dependent kinases(CDKs) ?

A: Cyclins are cellular elements that drive or regulate the events of the cell cycle by combining with…

Q: How is the signal generated by binding of TGF-β to cell-surface receptors transmitted to the…

A: TGF-β is a cytokine of the transforming growth factor family of signaling molecules with multiple…

Q: Why is it advantageous for p53 to be activated by factorssuch as ER stress, UV light, and hypoxia…

A: The p53 is known as tumor protein formed from the TP53 gene. The protein acts as a tumor suppressor…

Q: Explain how the specializations for M-phase function prevents the activities of Interphase,…

A: The cell cycle starts with resting (G0) phase. Then proceeding to interphase (G1 phase, S phase, G2…

Q: The balance between plus-end-directed and minus-end- directed motor proteins that bind to interpolar…

A: Microtubules are the rigid rod like structure which is hollow inside which helps in maintaining the…

Q: What is UPR? What is the downstream impact of UPR activation in an eucaryotic cell?

A: UPR stands for unfolded protein response. It is an intracellular signal transduction pathway that…

Q: Briefly describe how the cyclin D-cdk4/6 and cyclin E-cdk2 complexes regulate Retinoblastoma protein…

A: Retinoblastoma is the disease occurring in the retina of the eyes. This is basically eye cancer…

Q: Which are the events causing loss-of-heterozygosity in somatic cells of RB+/RB− individuals?

A: The DNA (deoxyribonucleic acid) is the genetic material that is inherited by the progeny from the…

Q: How does each of these small GTP-binding proteins contribute to the regulation of cell migration?

A: GTP bonding protein also known as G protein.G protein is present in eukaryotic and classifieds into…

Q: protein do cyclin – dependent kinases bind to become active?

A: Cyclin-dependent kinases are protein kinases that play a major role in cell cycle control. They…

Q: What is the structural basis ofchromosome condensation, andhow is the process stimulated…

A: Introduction  Cytology refers to the study of cells such as cell morphology, physiology, etc. As we…

Q: enzyme (Tyr 15 of phorylated, the en- -ylation state of any lows replication. The role of Cdk…

A: The cell cycle is highly regulated by different regulatory proteins that includes the cdc2 and…

Q: Suggest a mechanism by which ARF leads to p53 build-up.

A: p53 protein gets activated when there is a damage in  DNA sequence which can be induced by any other…

Q: Nucleation of straight, single line microfilaments is mediated by which of the following? Rho GTPase…

A: The nucleation of actin filaments is a tightly regulated process that involves several proteins.…

Q: Why is it disadvantageous for single-celled eukaryotes such as yeast to undergo apoptosis?

A: Apoptosis or programmed cell death is genetically regulated phenomenon of selective elimination of…

Q: What is the effect of having fluctuating cyclin levels throughout the cell cycle, while the levels…

A: Cell cycle  It is a series of events in which cell duplicate it's organelles and divide.

Q: The enzyme Ste11 participates in several distinct MAP kinase signaling pathways in the budding yeast…

A: Ste11 is the mitogen-activated protein kinase (MAPK). The MAPK cascades is involve in mating, high…

Q: Does TERT activation affect cancer development through other ways besides mediating telomere…

A: TERT means Telomerase reverse transcriptase and this enzyme help in the development of cancer .

Q: How did the intrinsic pathway ofapoptosis evolve, and what is theadvantage of having…

A: When a cell becomes dead this is known as Apoptosis. In Apoptosis the material present in the cell…

Q: Rather surprisingly, some cellular components that we know best from our study of nuclear protein…

A: Nuclear protein import is a selective process where all nuclear proteins are cytoplasm-synthesized…