Q.Consider this problem: You are working in the lab to study the pattern of paralysis and candidate genes involved in this process. You revealed that homozygous mutation in the SLB gene is the main cause of paralysis. The following sequence of SLB gene at the beginning of the translated region is found in individuals without paralysis. 5‟-GTA GCA TTT AAG CTT CAG TCC AAG - 3‟ (Met Thr Phe Glu Ile Gln Ser Arg). This sequence is however changed to the following sequence in affected individuals 5‟- GTA GCA TTT AAG CTT TAG TCC AAG - 3‟ (Met Thr Phe Glu Ile STOP). What mutation you will identify from this observation? Explain with reason. After identifying mutation if there is any, enlist all the possible repair mechanisms that can be helpful to repair the current situation. Elaborate your answer with that why you think that your suggested repair pathway should be used and how it can be effective for repairing in the current scenario?
Q.Consider this problem: You are working in the lab to study the pattern of paralysis and candidate genes involved in this process. You revealed that homozygous mutation in the SLB gene is the main cause of paralysis. The following sequence of SLB gene at the beginning of the translated region is found in individuals without paralysis. 5‟-GTA GCA TTT AAG CTT CAG TCC AAG - 3‟ (Met Thr Phe Glu Ile Gln Ser Arg). This sequence is however changed to the following sequence in affected individuals 5‟- GTA GCA TTT AAG CTT TAG TCC AAG - 3‟ (Met Thr Phe Glu Ile STOP). What mutation you will identify from this observation? Explain with reason. After identifying mutation if there is any, enlist all the possible repair mechanisms that can be helpful to repair the current situation. Elaborate your answer with that why you think that your suggested repair pathway should be used and how it can be effective for repairing in the current scenario?
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