a. What is the expected phenotype of an a cell in which HMRa has been deleted? [Select]

Define common variants

Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, Bcl-2, telomerase, jun, and

A. Describe in complete sentences how the requirement of a PAM sequence affects the flexibility of CRISPR-Cas9 gene editing.

Q. The nuclear membrane disintegrates late in prophase of mitosis in most eukaryotic cells. Once the membrane is reformed in telophase in a daughter cell, several components of gene expression might therefore be “caught” out in the cytoplasm when they would otherwise only ever be found inside the nucleus. Consider where the following components of gene expression are made and where they function. Which component is normally never found in the cytoplasm outside the nucleus? spliced intron RNA polymerase snRNA DNA polymerase   A. 1, 2 and 3 B. 1 and 3 C. 2 and 4 D. 4 only E. All of 1, 2, 3 & 4 are correct

Explain the normal regulation of proto-oncogenes and tumor suppressor genes that prevents cells from becoming cancerous.

Explain in general what is meant by a proto-oncogene and how they are involved in the formation of a tumor

"In most differentiated tissues, daughter cells retain a memory of gene expression patterns that were present in the parent cell through mechanisms that do not involve changes in the sequence of their genomic DNA" is true or false.

Explain Male- and female-specific forms of Dsx protein.

Describe how the anaphase-promoting complex (APC) is activated in cells (name the cellular/molecular components involved).