Glyceraldehyde-3-phosphate + NAD+ + Pi → 1,3-bisphosphoglycerate + NADH + H+ ∆G0’ =+6.3 kJ mol-1 ② NAD+ + H+ + 2e- → NADH ∆G0’ = +61.7 kJ mol-1 ③ Glyceraldehyde-3-phosphate + Pi → 1,3-bisphosphoglycerate + H+ + 2 e- ∆G0’ = ??? kJ mol-1 How are equations ② and ③ related to equation ①? b) Calculate the ∆G0’ for the formation of 1,3-bisphosphoglycerate from glyceraldehyde-3-phosphate and inorganic phosphate (reaction ③ above) c) Why is reaction ③ coupled with the reaction ② when reaction ② is so unfavorable, i.e., what is the chemical role of the NAD+?
Glyceraldehyde-3-phosphate + NAD+ + Pi → 1,3-bisphosphoglycerate + NADH + H+ ∆G0’ =+6.3 kJ mol-1 ② NAD+ + H+ + 2e- → NADH ∆G0’ = +61.7 kJ mol-1 ③ Glyceraldehyde-3-phosphate + Pi → 1,3-bisphosphoglycerate + H+ + 2 e- ∆G0’ = ??? kJ mol-1 How are equations ② and ③ related to equation ①? b) Calculate the ∆G0’ for the formation of 1,3-bisphosphoglycerate from glyceraldehyde-3-phosphate and inorganic phosphate (reaction ③ above) c) Why is reaction ③ coupled with the reaction ② when reaction ② is so unfavorable, i.e., what is the chemical role of the NAD+?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Glyceraldehyde-3-phosphate + NAD+ + Pi → 1,3-bisphosphoglycerate + NADH + H+
∆G0’ =+6.3 kJ mol-1
② NAD+ + H+ + 2e- → NADH ∆G0’ = +61.7 kJ mol-1
③ Glyceraldehyde-3-phosphate + Pi → 1,3-bisphosphoglycerate + H+ + 2 e-
∆G0’ = ??? kJ mol-1
How are equations ② and ③ related to equation ①?
b) Calculate the ∆G0’ for the formation of 1,3-bisphosphoglycerate from glyceraldehyde-3-phosphate and inorganic phosphate (reaction ③ above)
c) Why is reaction ③ coupled with the reaction ② when reaction ② is so unfavorable, i.e., what is the chemical role of the NAD+?
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