Exhibit 6A This is a reaction going on in your muscle cells right this very minute: dihydroxyacetone phosphate E+S k₁ k₁ 450 S-¹ The enzyme triose phosphate isomerase catalyzes this reaction in the forward direction as part of glycolytic pathway. It follows simple Michaelis-Menten kinetics: ES 500 s¹ glyceraldehyde-3-phosphate E+P Typical cellular concentrations triose phosphate isomerase = 0.1 nM dihydroxyacetone phosphate = 5 uM glyceraldehyde-3-phosphate=2 µM O a. This is a noncompetitive inhibitor. Ob. This is an irreversible inhibitor. Refer to Exhibit 6A. "Hindrate" is an inhibitor of triose phosphate isomerase. When it is added to cells at a concentration of 0.1 nM, the enzyme's KM for the substrate is unchanged, but the apparent Vmax is altered to 50 nM/sec. Oc. This is an uncompetitive inhibitor. Od. This is a competitive inhibitor +
Exhibit 6A This is a reaction going on in your muscle cells right this very minute: dihydroxyacetone phosphate E+S k₁ k₁ 450 S-¹ The enzyme triose phosphate isomerase catalyzes this reaction in the forward direction as part of glycolytic pathway. It follows simple Michaelis-Menten kinetics: ES 500 s¹ glyceraldehyde-3-phosphate E+P Typical cellular concentrations triose phosphate isomerase = 0.1 nM dihydroxyacetone phosphate = 5 uM glyceraldehyde-3-phosphate=2 µM O a. This is a noncompetitive inhibitor. Ob. This is an irreversible inhibitor. Refer to Exhibit 6A. "Hindrate" is an inhibitor of triose phosphate isomerase. When it is added to cells at a concentration of 0.1 nM, the enzyme's KM for the substrate is unchanged, but the apparent Vmax is altered to 50 nM/sec. Oc. This is an uncompetitive inhibitor. Od. This is a competitive inhibitor +
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 11P
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