Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman’s mother was affected while the father was normal. a. Indicate the gene notation. b. Give the genotypes of the affected boy’s parents. c. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. d. What is the probability that they will have a phenotypically normal daughter as their first child? e. If they have four children, what is the probability that three out of their four children will be normal and one will be affected
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman’s mother was affected while the father was normal.
a. Indicate the gene notation.
b. Give the genotypes of the affected boy’s parents.
c. Derive the genotypic and
d. What is the probability that they will have a phenotypically normal daughter as their first child?
e. If they have four children, what is the probability that three out of their four children will be normal and one will be affected?
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