Dent disease is reabsorption of filtered solutes and progressive renal failure. The following pedigree shows the pattern of inheritance for this disorder. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? From your answer to part a, give the most likely genotypes for the following ersons in the pedigree: -1: 1-2: -5: Il-8: 1-1: IlIl-3:

Over a thousand different alleles at the CFTR locus have been discovered that can cause cystic fibrosis. What difficulties might the presence of so many different alleles at this locus create for the diagnosis and treatment of cystic fibrosis?

The pedigree of a family with haemophilia as shown in Figure below .  If the gene for haemophilia is represented by Xh and the normal allele by X', write the genotypes of each individual in the pedigree. If the genotype cannot be determined with certainty write the possible alternatives.

Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body.   Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_  HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbA