Use the image below to answer the following questions.   Label the genotypes for ALL the family members in the pedigree above. Remember to use XX and XY when labeling. What does it mean to be a carrier? Why does Alexis have hemophilia? Is hemophilia a sex-linked disease? Wha

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  1. Use the image below to answer the following questions.

 

  1. Label the genotypes for ALL the family members in the pedigree above. Remember to use XX and XY when labeling.
  2. What does it mean to be a carrier?
  3. Why does Alexis have hemophilia?
  4. Is hemophilia a sex-linked disease? What does that mean and how does this pedigree show you this?
## Hemophilia in the Royal Family: A Case Study

This educational case study illustrates the inheritance pattern of hemophilia within a segment of the royal family tree. 

### Key
- **Unaffected individual**: Represented by a white square (males) or circle (females).
- **Carrier female**: Represented by a light pink circle.
- **Individual with hemophilia**: Represented by a red square (males).

### Pedigree Analysis

1. **Queen Victoria** and **Albert**:
   - Queen Victoria is depicted as a carrier of hemophilia (light pink circle).
   - Albert is unaffected (white square).

2. **Alice** and **Louis**:
   - Their daughter, Alice, also a carrier (light pink circle).
   - Louis is unaffected (white square).

3. **Alexandra** and **Czar Nicholas II of Russia**:
   - Alexandra, a carrier (light pink circle), is the daughter of Alice and Louis.
   - Czar Nicholas II is unaffected (white square).
   - Their son, Alexis, is affected by hemophilia (red square).

### Historical Context

The family photograph below the pedigree chart includes prominent historical figures, illustrating the real-life impact of genetic inheritance.

### Understanding Inheritance Patterns

Hemophilia is an X-linked recessive disorder. Women, having two X chromosomes, can be carriers if only one X chromosome carries the allele for hemophilia. Men, having only one X chromosome, are affected if their single X chromosome carries the allele for hemophilia. This case study clearly shows the transmission of the hemophilia allele through carriers (females) and its manifestation in affected males.

### Conclusion

The inheritance pattern of hemophilia in this royal family is a classic example of X-linked recessive disorders, demonstrating how genetic conditions can be passed through generations and the importance of genetic carriers in these patterns.
Transcribed Image Text:## Hemophilia in the Royal Family: A Case Study This educational case study illustrates the inheritance pattern of hemophilia within a segment of the royal family tree. ### Key - **Unaffected individual**: Represented by a white square (males) or circle (females). - **Carrier female**: Represented by a light pink circle. - **Individual with hemophilia**: Represented by a red square (males). ### Pedigree Analysis 1. **Queen Victoria** and **Albert**: - Queen Victoria is depicted as a carrier of hemophilia (light pink circle). - Albert is unaffected (white square). 2. **Alice** and **Louis**: - Their daughter, Alice, also a carrier (light pink circle). - Louis is unaffected (white square). 3. **Alexandra** and **Czar Nicholas II of Russia**: - Alexandra, a carrier (light pink circle), is the daughter of Alice and Louis. - Czar Nicholas II is unaffected (white square). - Their son, Alexis, is affected by hemophilia (red square). ### Historical Context The family photograph below the pedigree chart includes prominent historical figures, illustrating the real-life impact of genetic inheritance. ### Understanding Inheritance Patterns Hemophilia is an X-linked recessive disorder. Women, having two X chromosomes, can be carriers if only one X chromosome carries the allele for hemophilia. Men, having only one X chromosome, are affected if their single X chromosome carries the allele for hemophilia. This case study clearly shows the transmission of the hemophilia allele through carriers (females) and its manifestation in affected males. ### Conclusion The inheritance pattern of hemophilia in this royal family is a classic example of X-linked recessive disorders, demonstrating how genetic conditions can be passed through generations and the importance of genetic carriers in these patterns.
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