Use the image below to answer the following questions.   Label the genotypes for ALL the family members in the pedigree above. Remember to use XX and XY when labeling. What does it mean to be a carrier? Why does Alexis have hemophilia? Is hemophilia a sex-linked disease? Wha

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Topic Video
Question
  1. Use the image below to answer the following questions.

 

  1. Label the genotypes for ALL the family members in the pedigree above. Remember to use XX and XY when labeling.
  2. What does it mean to be a carrier?
  3. Why does Alexis have hemophilia?
  4. Is hemophilia a sex-linked disease? What does that mean and how does this pedigree show you this?
## Hemophilia in the Royal Family: A Case Study

This educational case study illustrates the inheritance pattern of hemophilia within a segment of the royal family tree. 

### Key
- **Unaffected individual**: Represented by a white square (males) or circle (females).
- **Carrier female**: Represented by a light pink circle.
- **Individual with hemophilia**: Represented by a red square (males).

### Pedigree Analysis

1. **Queen Victoria** and **Albert**:
   - Queen Victoria is depicted as a carrier of hemophilia (light pink circle).
   - Albert is unaffected (white square).

2. **Alice** and **Louis**:
   - Their daughter, Alice, also a carrier (light pink circle).
   - Louis is unaffected (white square).

3. **Alexandra** and **Czar Nicholas II of Russia**:
   - Alexandra, a carrier (light pink circle), is the daughter of Alice and Louis.
   - Czar Nicholas II is unaffected (white square).
   - Their son, Alexis, is affected by hemophilia (red square).

### Historical Context

The family photograph below the pedigree chart includes prominent historical figures, illustrating the real-life impact of genetic inheritance.

### Understanding Inheritance Patterns

Hemophilia is an X-linked recessive disorder. Women, having two X chromosomes, can be carriers if only one X chromosome carries the allele for hemophilia. Men, having only one X chromosome, are affected if their single X chromosome carries the allele for hemophilia. This case study clearly shows the transmission of the hemophilia allele through carriers (females) and its manifestation in affected males.

### Conclusion

The inheritance pattern of hemophilia in this royal family is a classic example of X-linked recessive disorders, demonstrating how genetic conditions can be passed through generations and the importance of genetic carriers in these patterns.
Transcribed Image Text:## Hemophilia in the Royal Family: A Case Study This educational case study illustrates the inheritance pattern of hemophilia within a segment of the royal family tree. ### Key - **Unaffected individual**: Represented by a white square (males) or circle (females). - **Carrier female**: Represented by a light pink circle. - **Individual with hemophilia**: Represented by a red square (males). ### Pedigree Analysis 1. **Queen Victoria** and **Albert**: - Queen Victoria is depicted as a carrier of hemophilia (light pink circle). - Albert is unaffected (white square). 2. **Alice** and **Louis**: - Their daughter, Alice, also a carrier (light pink circle). - Louis is unaffected (white square). 3. **Alexandra** and **Czar Nicholas II of Russia**: - Alexandra, a carrier (light pink circle), is the daughter of Alice and Louis. - Czar Nicholas II is unaffected (white square). - Their son, Alexis, is affected by hemophilia (red square). ### Historical Context The family photograph below the pedigree chart includes prominent historical figures, illustrating the real-life impact of genetic inheritance. ### Understanding Inheritance Patterns Hemophilia is an X-linked recessive disorder. Women, having two X chromosomes, can be carriers if only one X chromosome carries the allele for hemophilia. Men, having only one X chromosome, are affected if their single X chromosome carries the allele for hemophilia. This case study clearly shows the transmission of the hemophilia allele through carriers (females) and its manifestation in affected males. ### Conclusion The inheritance pattern of hemophilia in this royal family is a classic example of X-linked recessive disorders, demonstrating how genetic conditions can be passed through generations and the importance of genetic carriers in these patterns.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps with 1 images

Blurred answer
Knowledge Booster
Patterns of inheritance
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education