Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor anemia or a major anemia. Assuming that only a single gene pair and two alleles are involved in the inheritance of these conditions, is thalassemia a dominant or recessive disorder?
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Thalassemia is an inherited anemic disorder in humans. Affected
individuals exhibit either a minor anemia or a major anemia.
Assuming that only a single gene pair and two alleles are involved
in the inheritance of these conditions, is thalassemia a dominant
or recessive disorder?
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- Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16. The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition. Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why? A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobinSuppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.) A) None of their children will have sickle-cell disease. B) All of their children will have sickle-cell disease. C) All of the couple's children would be heterozygous carriers like the mother.
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman's mother was affected while the father was normal. Indicate the gene notation. Give the genotypes of the affected boy's parents. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. What is the probability that they will have a phenotypically normal daughter as their first child? a. b. С. d.Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal function of red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found on the X chromosome. An affected son was born to a man and woman who were unaffected. The woman's mother was affected while the father was normal. Indicate the gene notation. Give the genotypes of the affected boy's parents. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. What is the probability that they will have a phenotypically normal daughter as their first child? а. b. С. d.A man with thalassemia minor marries a normal woman. What phenotypic ratios of thalassemia-affected children might these parents expect?
- Porphyria is a genetic disorder caused by the inability to properly metabolize a component of hemoglobin. King George III is suspected to have been afflicted with this disorder. Assume that both George and his Queen suffered from this disorder and they had one afflicted child and one normal child. Is porphyria inherited in a dominant or recessive fashion? What must be the genotype of both George and his Queen? Using punnett square, show ALL work used to achieve your answer.Sickle cell anemia is inherited as an autosomal recessive condition. It also exhibits incomplete dominance in that the heterozygous genotype displays a mild form of the disease known as sickle cell trait while individuals with the homozygous recessive genotype have a severe form of SCA. A man who has severe sickle cell anemia marries a woman who suffers from a mild trait. What is the probabilitu they will have a child with severe SCA?What is the probability they will have a child with mild SCA? What is the probability they will have a normal child? Show ALL work using punnett squares.How does a positive ASO test for sickle-cell anemia determine that an individual is homozygous recessive for the mutation that causes sickle-cell anemia?
- Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?a) Identify and describe 5 different types of genetic inheritance.(b) In humans, glucose-6-phosphate dehydrogenase deficiency is a recessive X-linkedtrait. Describe the inheritance of this disease, including an example of the possibleoutcomes of:(i) An affected mother and an unaffected father having children. (ii) An affected father and a homozygous unaffected mother having childrenSickle cell anemia is a human genetic disorder caused by an autosomal recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?