Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 7, Problem 111P
To determine
State the estimate for the risk rate of major cardiovascular
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A clinical trial is planned to compare an experimental medication designed to lower blood pressure to a pla- cebo. Before starting the trial, a pilot study is conducted involving seven participants. The objective of the study is to assess how systolic blood pressure (SBP) changes over time if left untreated. SBP is measured at baseline and again 4 weeks later. Is there a statistically significant difference in SBP over time? Run the test at a 5% level of significance.
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Chapter 7 Solutions
Fundamentals of Biostatistics
Ch. 7.3 - What is the difference between a type I and type...Ch. 7.3 - What is the difference between the critical-value...Ch. 7.3 - Several studies have shown that women with many...Ch. 7.7 - In the BMD study referred to in Case Study 2 (p....Ch. 7.7 - Prob. B.2RECh. 7.7 - Prob. B.3RECh. 7.9 - Prob. C.1RECh. 7.9 - Prob. C.2RECh. 7.9 - How much power did the test in Review Question...Ch. 7 - The mean serum-creatinine level measured in 12...
Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 1 2...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serumcreatinine level measured in 12...Ch. 7 - The mean serumcreatinine level measured in 12...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the annual incidence of asthma in the...Ch. 7 - Prob. 18PCh. 7 - Suppose the annual incidence of asthma in the...Ch. 7 - Prob. 20PCh. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Suppose we identify 50 women 50 to 54 years of age...Ch. 7 - The drug erythromycin has been proposed to...Ch. 7 - A pilot study of a new antihypertensive agent is...Ch. 7 - A pilot study of a new antihypertensive agent is...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Prob. 60PCh. 7 - Previous studies have shown that supplementing the...Ch. 7 - Prob. 62PCh. 7 - Prob. 63PCh. 7 - Previous studies have shown that supplementing the...Ch. 7 - Prob. 65PCh. 7 - Prob. 66PCh. 7 - Refer to Data Set NIFED.DAT at...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - Prob. 72PCh. 7 - Breast cancer is strongly influenced by a womans...Ch. 7 - Prob. 74PCh. 7 - An investigator wants to test a new eye drop that...Ch. 7 - Prob. 76PCh. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Prob. 81PCh. 7 - Prob. 82PCh. 7 - Concurrent sexual partnerships are widely believed...Ch. 7 - Prob. 84PCh. 7 - Prob. 85PCh. 7 - Prob. 86PCh. 7 - Consider the birthweight data in Example 7.2. What...Ch. 7 - Consider the birthweight data in Example 7.2. Now...Ch. 7 - Prob. 89PCh. 7 - A screening program for neuroblastoma (a type of...Ch. 7 - A screening program for neuroblastoma (a type of...Ch. 7 - Prob. 92PCh. 7 - Prob. 93PCh. 7 - Prob. 94PCh. 7 - Prob. 95PCh. 7 - Prob. 96PCh. 7 - An experiment was performed to assess the efficacy...Ch. 7 - Medical errors are common in hospitals throughout...Ch. 7 - Prob. 99PCh. 7 - Prob. 100PCh. 7 - Prob. 101PCh. 7 - Prob. 102PCh. 7 - Prob. 103PCh. 7 - Prob. 104PCh. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Prob. 108PCh. 7 - Prob. 109PCh. 7 - Prob. 110PCh. 7 - Prob. 111PCh. 7 - Prob. 112PCh. 7 - Prob. 113PCh. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - Prob. 117PCh. 7 - Prob. 118PCh. 7 - Prob. 119PCh. 7 - Prob. 120PCh. 7 - Prob. 121P
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- What is an experiment?arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 26% developed cervical cancer, and based on a sample of 100 women in the placebo group, 32% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 26% developed cervical cancer, and based on a sample of 100 women in the placebo group, 32% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forward
- Most cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 34 % developed cervical cancer, and based on a sample of 100 women in the placebo group, 44 % developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forwardIn an observational study it was found that people who had received the flu shot this year had better blood pressure readings, on average, than people who did not. Can it be claimed that the flu shot is the cause of the lower overall blood pressure? Why or why not?arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 34 % developed cervical cancer, and based on a sample of 100 women in the placebo group, 44% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forward
- Although arsenic is known to be a poison, it also has some beneficial medicinal uses. In one study of the use of arsenic to treat acute promyelocytic leukemia (APL), a rare type if blood cancer, APL patients were given an arsenic compound as part of their treatment. Of those receiving arsenic, 32% were in remission and showed no signs of leukemia in subsequent examination. It is known that 18% of APL patients go into remission after conventional treatment. Suppose that the study had included 100 randomly selected patients. Is there sufficient evidence to conclude that the proportion in remission for the arsenic treatment is greater than 0.18, the remission proportion for conventional treatment? a. Test the hypothesis at the 0.01 significance level. b. Construct and interpret a 99% confidence interval for the true proportion of APL patients who go into remission after using arsenic. Does the inference drawn from this interval match the conclusion from the test that you did in part…arrow_forwardIndomethacin is one type of non-steroidal anti-inflammatory drug that is given to people diagnosed with ankylosing spondylitis (or AS, a rare kind of arthritis) to suppress pain. It is observed that this medication takes effect up until 4 weeks after regular intake. However, due to medical advancement, we expect that it will take less than the reported time interval. To confirm this, a researcher gathered 15 randomly selected patients with AS, and recorded the time it took for the pain, swelling, or stiffness to be relieved after indomethacin intake (in weeks). If the true average weeks is less than 4 and we fail to reject the null hypothesis, did a type I, type II, or no error occur? (Source: Smith, M. (2020, October 13). Ankylosing Spondylitis (AS); Symptoms, Causes, Diagnosis, Treatment, and Prognosis. Retrieved from https://www.webmd.com/arthritis/what-is-ankylosing- spondylitis) No error has occurred Type II Error has occurred Both Type I and Type II Errors have occurred O Type I…arrow_forwardResearchers have noted a decline in cognitive functioning as people age (Bartus, 1990). However, the results from other research suggest that the antioxidants in foods such as blueberries may reduce and even reverse these age-related declines (Joseph et al., 1999). To examine this phenomenon, suppose that a researcher obtains a sample of n = 16 adults who are between the ages of 65 and 75. The researcher uses a standardized test to measure cognitive performance for each individual. The participants then begin a 2-month program in which they receive daily doses of a blueberry supplement. At the end of the 2-month period, the researcher again measures cognitive performance for each participant. The results show an average increase in performance of MD = 7.4 with SS = 1215. Does this result support the conclusion that the antioxidant supplement has a significant effect on cognitive performance? Use a two-tailed test with α = .05. Show your computations.arrow_forward
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