Previous studies have shown that supplementing the diet with oat bran may lower serum-cholesterol levels. However, it is not known whether the cholesterol is reduced by a direct effect of oat bran or by replacing fatty foods in the diet. To address this question, a study was performed to compare the effect of dietary supplementation with high-fiber oat bran (87 g/day) to dietary supplementation with a low-fiber refined wheat product on the serum cholesterol of 20 healthy participants ages 23-49 years [3]. Each subject had a cholesterol level measured at baseline and then was randomly assigned to receive either a high-fiber or a low-fiber diet for 6 weeks. A 2-week period followed during which no supplements were taken. Participants then took the alternate supplement for a 6-week period. The results are shown in Table 7.7.
Note: Plus-minus (±) value are
How many participants would be needed to have a 90% chance of finding a significant difference in mean cholesterol lowering between the high- and low-fiber diets if the high-fiber diet lowers mean cholesterol by 5 mg/dL more than the low-fiber diet and a two-sided test is used with significance level = .05?
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Fundamentals of Biostatistics
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