Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 41, Problem 3Q
Summary Introduction
To review:
The advantage of the gene therapy on the patients who were also given enzyme replacement therapy (ERT).
Introduction:
Immunodeficiency refers to the condition that arises due to the inability of the body’s immune system to efficiently tackle the infectious agents and fight against the diseases. The individual becomes susceptible to even smallest type of infection as the immunity of the body weakens or is totally absent. These diseases can be inherited from one generation to another.
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Discuss an example of ex vivo and of in vivo genetherapy.
What are the considerations for choice of a vector in gene therapy?
Describe some methods used to deliver normal genes to cells for gene therapy treatments.
Chapter 41 Solutions
Life: The Science of Biology
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- Explain how therapeutic genes may be delivered topatientsarrow_forwardProvide a brief summary (3 – 5 sentences) about information of the GATA3 gene (frequency of mutations, types of mutations, details of patient data such as health symptoms expressed due to the mutated gene above , etc.).arrow_forwardExplain the difference between in vivo and ex vivogene therapy.arrow_forward
- Why is it necessary to examine gene-expression profiles, in additionto genome sequences, for effective precision medicine?arrow_forwardIn selecting target cells to receive a transferred gene in gene therapy, what factors do you think would have to be taken into account? Explain your answer.arrow_forwardGive a schematic diagram of how we can Treatment Hemophilia by using gene therapy? Please answer at your own words,please..arrow_forward
- Compare and contrast the advantages and disadvantages of production of genetically modified crps.arrow_forwardExplain some barriers that must be overcome before gene therapy becomes a safe, practical, effective, and well-established approach to treating disease.arrow_forwardWhich of the following best describes the approach that wasused in the first gene therapy trial for treating SCID?a. The normal ADA gene was introduced by injecting liposomesdirectly into the patients’ bodies. b. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes vialiposomes,and then the lymphocytes were returned to thepatient’s body.c. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes via a retrovirus,and then the lymphocytes were returned to thepatient’s body.d. None of the above describe the approach used in the trial.arrow_forward
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