Chapter 4, Problem 31P

Human ABO blood type is determined by three alleles, two of which (IA and IB) produce gene products that modify the antigen produced by protein activity of an independently assorting H gene. A rare abnormality known as the Bombay phenotype” is the result of epistatic interaction etween the gene for the ABO blood group and the H gene. ndividuals with the Bombay henotype appear to have lood type O based on the inability of both anti-A antibody nd anti-B antibody to detect an antigen. The apparent lood type O in Bombay phenotype is due to the absence of antigen as a result of homozygous recessive mutations of he H gene. Individuals with the Bombay phenotype have he hh genotype. Use the information above to make predictions bout the outcome of the cross shown below.

${\text{I}}^{\text{A}}{\text{I}}^{\text{B}}{\text{Hh×I}}^{\text{A}}{\text{I}}^{\text{B}}\text{Hh}$