Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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In humans, the genes for red-green color blindness (R = normal, r = color blind) and hemophilia A (H = normal, h = hemophilia) are both X-linked and only 3 map units apart.
Suppose a woman has four sons, and two are color blind but have normal blood clotting and two have hemophilia but normal color vision. What is the probable genotype of the woman?
- HR/hr
- Hr/hr
- hr/hR
- Hr/hR
- HR/Hr
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- Hemophilia, disease in which the blood lacks a clotting factor, is caused by an X linked recessive gene. Joe doe not have hemophilia and Lucille is heterozygous for the condition. What is the chance that their MALE child will have hemophilia? (Note: you are calculating the probability for their MALE children only, in other words if they have 1 male child, what is the probability that he will be born with the disease?) 0% 1/4 or 25% 2/4 or 50% 3/4 or 75% 4/4 or 100%arrow_forwardDraw the punnet square and explain the resultsarrow_forwardSeveral genes in humans in addition to the ABO gene () give rise to recognizable antigens on the surface of the red blood cells. The Rh marker is determined by positive (R) and negative alleles () of gene R, where R is completely dominant to r. The presence of M and N surface proteins are controlled by two codominant alleles of gene L (LM and LM. For each mother-child pair, choose the father of the child from among the males in the right column. (Assume that all mothers and fathers are HH; there is no involvement of the Bombay phenotype.) Paternal genotypes maybe used once, more than once, or not at all. Each mother-child pair matches with one or more than one paternal genotype. Maternal phenotype: Child phenotype: Paternal genotype: Reset A, M, Rh(neg) O, M, Rh(pos) B, N, Rh(neg) O, N, Rh(pos) O, M, Rh(neg) A, MN, Rh(pos) A, N, Rh(pos) AB, MN, Rh(pos) B, N, Rh(pos) A, MN, Rh(neg) Genotypes of possible fathers AiLMLN rr BiLMLN RR ii LNLN rr ii LMLM rr AALMLN RRarrow_forward
- In 1952, an article in the British Medical Journalreported interesting differences in the behavior ofblood plasma obtained from several people who suffered from X-linked recessive hemophilia. Whenmixed together, the cell-free blood plasma from certain combinations of individuals could form clots inthe test tube. For example, the following table showswhether clots could form (+) or not (−) in variouscombinations of plasma from four people withhemophilia:1 and 1 − 2 and 3 +1 and 2 − 2 and 4 +1 and 3 + 3 and 3 −1 and 4 + 3 and 4 −2 and 2 − 4 and 4 −What do these data tell you about the inheritance ofhemophilia in these individuals? Do these data allowyou to exclude any models for the biochemical pathway governing blood clotting?arrow_forwardIf a man with type O blood has a child with a woman who is heterozygous for type B blood, what are the possible blood types for this child?arrow_forwardGive the typical sex-chromosome complement found in the cells of people with Turner syndrome, with Klinefelter syndrome, and with androgen-insensitivity syndrome. What is the sex-chromosome complement of triple-X females?arrow_forward
- Duchenne’s muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness and is often fatal. “XD” represents the wild type allele, and “Xd,” the mutant allele. Jonah is XDXd Y and his brother Pete is Xd Y. Jonah and Pete BOTH have DMD of equal severity and phenotypes. You might have thought Jonah’s DMD would be less severe given his genotype. To better understand the situation, you investigate Jonah’s Xist chromosome region in his defective muscle cells. Which of the following is consistent with his phenotype? (Select all that apply.) The Xd-containing chromosome is inactive in defective muscle cells. The XD-containing chromosome has a methylated Xist promoter. The XD-containing chromosome has an unmethylated Xist promoter. The Xd-containing chromosome is active in defective muscle cells.arrow_forwardX-linked Recessive Inheritance A gene is described as X-linked when it occurs on the X chromosome and not the Y. Our convention is to indicate X-linkage by attaching the appropriate gene symbol as a superscript on the letter X. Commonly, the wild-type (+) allele is indicated with only a "+" to avoid having to type a superscript on a superscript. For example, a female that is heterozygous and carrying a recessive mutant allele is indicated as X+Xm. Note the convenience of the shorthand + for m+ in this situation. A mutant male has the genotype XmY. When working with X-linked inheritance, always include the X and Y chromosomes in the descriptions of genotypes, and include the sex (male or female) in the descriptions of the phenotypes (e.g., mutant male, wild-type female, etc.). Here are the genotypes and associated phenotypes for X-linked recessive inheritance: X+X+ Wild-type female X+Xm Wild-type female xmxm Mutant female X+Y xmy Wild-type male Mutant malearrow_forwardHow many males have hemopilia? (refer to image).arrow_forward
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