Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 4, Problem 14QP
Analysis of Autosomal Recessive and Dominant Traits
Huntington disease is a rare, fatal disease that usually develops in the fourth or fifth decade of life. It is caused by a single autosomal dominant allele. A
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Neo-Mendelian Genetics: Complete dominance and overdominance
Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia.
What are the genotypes of Mary and Paul?
If they plan to have four children, what is the probability that:
all their children will be normal? ____________
they will have a son with Huntington’s disease? ___________
they will have a daughter inflicted with both conditions?____________
Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Usher’s Syndrome is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. One website (http://www.emedicine.com/oph/topic704.htm) says that Usher’s Syndrome Type II has been mapped to chromosome arm 1qe. Usher’s Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition
1) Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Within this pedigree, include Eric's parents, Eric himself, Eric's brother Dirk, and a daughter of Eric's. Be sure to follow all standard pedigree conventions.
2) Imagine you are a genetics counselor. Based upon the pattern of inheritance, what advice would you give Eric's…
Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia.
1. Give the genotypes of Jillian and Jacob.
Assuming that they will have 4 children, what is the probability that:
2. all their children will be normal?
3. they will have a son with Huntington’s disease?
4. they will have a daughter inflicted with both conditions
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Analysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits A young boy is color-blind. His one brother and five sisters are not. The boy has three maternal uncles and four maternal aunts. None of his uncles children or grandchildren is color-blind. One of the maternal aunts married a color-blind man, and half of her children, both male and female, are color-blind. The other aunts married men who have normal color vision. All their daughters have normal vision, but half of their sons are color-blind. a. Which of the boys four grandparents transmitted the gene for color blindness? b. Are any of the boys aunts or uncles color-blind? c. Is either of the boys parents color-blind?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forward
- Analysis of Autosomal Recessive and Dominant Traits a. What pattern of inheritance is suggested by the following pedigree? b. For genotype assignment, assume that the pedigree is for an autosomal dominant trait and that the affected male in the first generation is heterozygous. Assign genotypes to all other individuals in the pedigree.arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits The following is a pedigree for a common genetic trait. Analyze the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Describe the phenotype and primary gene or protein defect of the X-linked recessive disease muscular dystrophy.arrow_forward
- Analysis of Autosomal Recessive and Dominant Traits Does the indicated individual (III-5) show the trait in question?arrow_forwardCystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?arrow_forward
- young couple is planning to have children. The male is heterozygous for Huntington’s disease and homozygous dominant for Tay-Sachs. The female is homozygous recessive for Huntington’s disease and heterozygous for Tay-Sachs. The couple is curious about the possibility and probability of their offspring inheriting Tay-Sachs and/or Huntington’s. For humans, Huntington’s disease is dominant (H) over the “normal” condition (h), and the “normal” condition is dominant (T) over Tay-Sachs (t). Complete a Punnett square for this cross and record the percent probabilities for genotypes and phenotypes of the offspring.arrow_forwardO O c. A person who has a gene allele for a disorder with reduced penetrance (60%) that is transmittedin an autosomal dominant pattern and is usually expressed after age 30 has reached the age of 50 without any manifestations of the disorder. He now states that he wishes that he had decided to have children now that he knows he cannot pass the disorder on to any children he fathered. Is this man's thinking correct? Explain This person is not right because he can still pass the disorder to his offspring. Penetrance is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype). The individual exhibits signs and symtoms of genetic disorder. He did not develop features of the disorder, the condition is said to have reduced (or incomplete) penetrance. He is a carrier of the allele for this disorder. As carrier he can give the genetic information to his child who could have a complete penetrance and…arrow_forwardWhat is the mode of inheritance shown here? Sex-linked recessive Autosomal recessive Autosomal dominant Sex-linked dominantarrow_forward
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