Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 4, Problem 8QP
Analysis of Autosomal Recessive and Dominant Traits
In the following pedigree, assume that the father of the proband is homozygous for a rare trait. What pattern of inheritance is consistent with this pedigree? In particular, explain the
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Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).
Karyogram and Identification of Chromosomal Aberrations
List down five human chromosomal aberrations. Give the corresponding karyotype for each type then briefly describe the traits of affected individuals.
Genetic cross with dependent assortment (linked traits). Repeat the previous problem but assume that the genes are located very close to each other on the same chromosome, and are therefore always linked (passed on together). Assume that in these individuals, each chromosome contains the dominant allele for one gene and the recessive allele for the other gene. Note: this is similar to the dependent assortment example in your notes, but the linkage is different. Construct a 2x2 Punnett square, and answer the questions below:
GgBb x GgBb
GB
Gb
gB
gb
GB
GGBB
GGBb
GgBB
GgBb
Gb
GGBb
GGbb
GgBb
Ggbb
gB
GgBB
GgBb
ggBB
ggBb
gb
GgBb
Ggbb
ggBb
ggbb
a) From your Punnett square, how many individuals are dihybrids?
b) How many individuals are both homozygous recessive for coat color and heterozygous for eye color (ggBb)?
c) Fill in the blanks to state the expected phenotypic ratio of the offspring:…
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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- Analysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits The father of 12 children begins to show symptoms of Huntington disease. a. What is the probability that Sam, the mans second-oldest son (II-2), will suffer from the disease if he lives a normal life span? (Sams mother and her ancestors do not have the disease.) b. Can you infer anything about the presence of the disease in Sams paternal grandparents?arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedarrow_forward
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Does the indicated individual (III-5) show the trait in question?arrow_forwardAnalysis of Autosomal Recessive and Dominant Traits Using the following pedigree, deduce a compatible pattern of inheritance. Identify the genotype of the individual in question.arrow_forward
- In the following pedigree, is the disorder’s mode of inheritanceautosomal dominant, autosomal recessive, or X-linked recessive?Explain your reasoning.arrow_forwardProgeny of triploid tomato plants often contain parts of an extra chromosome, in addition to the normal complement of 24 chromosomes . Mutantswith a part of an extra chromosome are referred to as secondaries. James and Margaret Lesley observed that secondaries arise from triploid (3 n), trisomic (3 n + 1), and double trisomic (3 n + 1 + 1) parents, but never from diploids (2 n). Give one or more possible reasons that secondaries arise from parents that have unpaired chromosomes but not from parents that are normal diploids.arrow_forwardCould the pedigree in Figure 2-31 be explained as an autosomal dominant disorder? Explain.arrow_forward
- based on fig 1. Is this karyotype a male or female? Is there a chromosomal disorder? What type of chromosomal disorder?arrow_forwardGene A and gene by 1bcM. A women with the genokype aabb has children with a man who is Aabb and the man's Parher was AABB. B ave two linked geres which are separated I) what is the probability meir first child uwill be Aabb? 2) what is the probability xheir furst two children will be Aabb?arrow_forwardMany genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?arrow_forward
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