Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Question
Chapter 3, Problem 47P
Summary Introduction
a.
To determine:
Whether the description of individuals with spherocytosis represents incomplete penetrance, variable expressivity, or both. Also, whether an individual derive any values from numerical data to measure incomplete penetrance or variable expressivity.
Introduction:
Penetrance refers to the proportion of people with a particular genotype who show the expected
Summary Introduction
b.
To determine:
The treatment for spherocytosis and the way incomplete dominance or variable expressivity would affect the treatment.
Introduction:
The degree or intensity with which a particular genotype is expressed in a phenotype is known as expressivity.
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Spherocytosis is an inherited blood disease in whichthe erythrocytes (red blood cells) are spherical insteadof biconcave. This condition can be inherited in adominant fashion, with ANK1 (the nonfunctional mutant allele) dominant to ANK1+. In people with spherocytosis, the spleen recognizes the spherical redblood cells as defective and removes them from thebloodstream, leading to anemia. The spleen in different people removes the spherical erythrocytes withdifferent efficiencies. Some people with sphericalerythrocytes suffer severe anemia and some mild anemia, yet others have spleens that function so poorly nosymptoms of anemia exist at all. When 2400 peoplewith the genotype ANK1 ANK1+ were examined, itwas found that all of them had spherical erythrocytes,2250 had anemia of varying severity, and 150 had nosymptoms. (Assume that ANK1 ANK1 homozygotesdo not exist.)a. Does this description of people with spherocytosisrepresent incomplete penetrance, variable expressivity, or both? Explain…
α-thalassemia is another blood disorder in which abnormal hemoglobin molecules are formed, leading to anemia. One mutant allele known to cause α-thalassemia occurs in α-hemoglobin and is called Constant Spring. Normal α-hemoglobin is 141 amino acids long, while the Constant Spring protein is 172 amino acids long. Include answers to both A and B in your response. A maximum of 2 sentences per part.
A) Explain how a frameshift mutation in the coding region of α-hemoglobin could result in the Constant Spring protein.
B) Explain how a single base-substitution mutation in the coding region of α-hemoglobin could result in the Constant Spring protein.
Several genes in humans in addition to the ABO gene () give rise to recognizable antigens on the surface of the red blood cells. The
Rh marker is determined by positive (R) and negative alleles () of gene R, where R is completely dominant to r. The presence of M and
N surface proteins are controlled by two codominant alleles of gene L (LM and LM. For each mother-child pair, choose the father of
the child from among the males in the right column. (Assume that all mothers and fathers are HH; there is no involvement of the
Bombay phenotype.)
Paternal genotypes maybe used once, more than once, or not at all. Each mother-child pair matches with one or more than one
paternal genotype.
Maternal phenotype:
Child phenotype:
Paternal genotype:
Reset
A, M, Rh(neg)
O, M, Rh(pos)
B, N, Rh(neg)
O, N, Rh(pos)
O, M, Rh(neg)
A, MN, Rh(pos)
A, N, Rh(pos)
AB, MN, Rh(pos)
B, N, Rh(pos)
A, MN, Rh(neg)
Genotypes of
possible fathers
AiLMLN rr
BiLMLN RR
ii LNLN rr
ii LMLM rr
AALMLN RR
Chapter 3 Solutions
Genetics: From Genes to Genomes
Ch. 3 - For each of the terms in the left column, choose...Ch. 3 - In four-oclocks, the allele for red flowers is...Ch. 3 - The Aa heterozygous snapdragons in Fig. 3.3 are...Ch. 3 - Recall from Chapter 2 Fig. 2.20 that Mendels R...Ch. 3 - In the fruit fly Drosophila melanogaster, very...Ch. 3 - A cross between two plants that both have yellow...Ch. 3 - In radishes, color and shape are each controlled...Ch. 3 - A wild legume with white flowers and long pods is...Ch. 3 - Assuming no involvement of the Bombay phenotype in...Ch. 3 - Several genes in humans in addition to the ABO...
Ch. 3 - Alleles of the gene that determines seed coat...Ch. 3 - One of your fellow students tells you that there...Ch. 3 - In a population of rabbits, you find three...Ch. 3 - In clover plants, the pattern on the leaves is...Ch. 3 - Fruit flies with one allele for curly wings Cy and...Ch. 3 - In certain plant species such as tomatoes and...Ch. 3 - In a species of tropical fish, a colorful orange...Ch. 3 - People heterozygous for normal and nonfunctional...Ch. 3 - Using old Fugate family Bibles and the Perry...Ch. 3 - A rooster with a particular comb morphology called...Ch. 3 - A black mare was crossed to a chestnut stallion...Ch. 3 - Filled-in symbols in the pedigree that follows...Ch. 3 - You perform a cross between two true-breeding...Ch. 3 - a. How would you describe inheritance of flower...Ch. 3 - Suppose the intermediate called Colorless...Ch. 3 - Explain the difference between epistasis and...Ch. 3 - The dominant allele H reduces the number of body...Ch. 3 - Secretors genotypes SS and Ss secrete their A and...Ch. 3 - Normally, wild violets have yellow petals with...Ch. 3 - A woman who is blood type B has a child whose...Ch. 3 - The following table shows the responses of blood...Ch. 3 - Three different pure-breeding strains of corn that...Ch. 3 - In mice, the AY allele of the agouti gene is a...Ch. 3 - A student whose hobby was fishing pulled a very...Ch. 3 - Suppose that blue flower color in a plant species...Ch. 3 - This problem examines possible biochemical...Ch. 3 - Considering your answers to Problem 36, does the...Ch. 3 - You picked up two mice one female and one male...Ch. 3 - Figure 3.21 and Fig. 3.28b both show traits that...Ch. 3 - Three genes in fruit flies affect a particular...Ch. 3 - The garden flower Salpiglossis sinuata painted...Ch. 3 - In foxgloves, three different petal phenotypes...Ch. 3 - In a culture of fruit flies, matings between any...Ch. 3 - Prob. 44PCh. 3 - A couple wants to know the probability that their...Ch. 3 - This problem illustrates why classical geneticists...Ch. 3 - Prob. 47PCh. 3 - Familial hypercholesterolemia FH is an inherited...Ch. 3 - You have come into contact with two unrelated...Ch. 3 - Polycystic kidney disease is a dominant trait that...Ch. 3 - Identical monozygotic twins have similar, but not...Ch. 3 - Using each of the seven coat color genes discussed...
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