Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 3, Problem 37P
Considering your answers to Problem 36, does the existence of a particular variation of a 9:3:3:1 ratio among the F2 progeny allow you to infer the operation of a specific biochemical mechanism responsible for these
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Consider two hypothetical recessive autosomal genes a and b, where a heterozygote is testcrossed to a double- homozygous mutant. Predict the phenotypic ratios under the following conditions: (a) a and b are located on separate autosomes. (b) a and b are linked on the same autosome but are so far apart that a crossover always occurs between them. (c) a and b are linked on the same autosome but are so close together that a crossover almost never occurs.
Susan’s grandfather was deaf, and passed down a hereditary form of deafness within Susan’s family as shown in Figure Q19–12.A. Is this mutation most likely to be dominant or recessive?B. Is it carried on an autosome or a sex chromosome? Why?C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected, and 7 unaffected). In comparing these 11 SNP results, how long a haplotype block would you expect to find around the critical gene? How might you detect it?
3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the cross you perform to determine if it is a dominant or recessive mutation compared to the WT gene P allele. Write the expected ratios for either scenario.
4) You have determined the mutation is dominant when compared to the WT allele. Briefly describe a technique you could use to determine if expression levels of gene P have been altered in this mutant.
5) You have determined the expression level of gene P has increased. What class/type of mutation would cause this?
Chapter 3 Solutions
Genetics: From Genes to Genomes
Ch. 3 - For each of the terms in the left column, choose...Ch. 3 - In four-oclocks, the allele for red flowers is...Ch. 3 - The Aa heterozygous snapdragons in Fig. 3.3 are...Ch. 3 - Recall from Chapter 2 Fig. 2.20 that Mendels R...Ch. 3 - In the fruit fly Drosophila melanogaster, very...Ch. 3 - A cross between two plants that both have yellow...Ch. 3 - In radishes, color and shape are each controlled...Ch. 3 - A wild legume with white flowers and long pods is...Ch. 3 - Assuming no involvement of the Bombay phenotype in...Ch. 3 - Several genes in humans in addition to the ABO...
Ch. 3 - Alleles of the gene that determines seed coat...Ch. 3 - One of your fellow students tells you that there...Ch. 3 - In a population of rabbits, you find three...Ch. 3 - In clover plants, the pattern on the leaves is...Ch. 3 - Fruit flies with one allele for curly wings Cy and...Ch. 3 - In certain plant species such as tomatoes and...Ch. 3 - In a species of tropical fish, a colorful orange...Ch. 3 - People heterozygous for normal and nonfunctional...Ch. 3 - Using old Fugate family Bibles and the Perry...Ch. 3 - A rooster with a particular comb morphology called...Ch. 3 - A black mare was crossed to a chestnut stallion...Ch. 3 - Filled-in symbols in the pedigree that follows...Ch. 3 - You perform a cross between two true-breeding...Ch. 3 - a. How would you describe inheritance of flower...Ch. 3 - Suppose the intermediate called Colorless...Ch. 3 - Explain the difference between epistasis and...Ch. 3 - The dominant allele H reduces the number of body...Ch. 3 - Secretors genotypes SS and Ss secrete their A and...Ch. 3 - Normally, wild violets have yellow petals with...Ch. 3 - A woman who is blood type B has a child whose...Ch. 3 - The following table shows the responses of blood...Ch. 3 - Three different pure-breeding strains of corn that...Ch. 3 - In mice, the AY allele of the agouti gene is a...Ch. 3 - A student whose hobby was fishing pulled a very...Ch. 3 - Suppose that blue flower color in a plant species...Ch. 3 - This problem examines possible biochemical...Ch. 3 - Considering your answers to Problem 36, does the...Ch. 3 - You picked up two mice one female and one male...Ch. 3 - Figure 3.21 and Fig. 3.28b both show traits that...Ch. 3 - Three genes in fruit flies affect a particular...Ch. 3 - The garden flower Salpiglossis sinuata painted...Ch. 3 - In foxgloves, three different petal phenotypes...Ch. 3 - In a culture of fruit flies, matings between any...Ch. 3 - Prob. 44PCh. 3 - A couple wants to know the probability that their...Ch. 3 - This problem illustrates why classical geneticists...Ch. 3 - Prob. 47PCh. 3 - Familial hypercholesterolemia FH is an inherited...Ch. 3 - You have come into contact with two unrelated...Ch. 3 - Polycystic kidney disease is a dominant trait that...Ch. 3 - Identical monozygotic twins have similar, but not...Ch. 3 - Using each of the seven coat color genes discussed...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forwardThe fruit fly Drosophila melanogaster has about 2 x 10^8 base pairs of DNA per haploid genome, of which about 75% in nonrepeated DNA. The DNA is distributed among four pairs of homologous chromosomes, which have a total of about 5,000 visible bands when in polytene forms in the salivary gland. The number of genes initially estimated from mutational studies was also about 5,000 but recent DNA sequencing studies suggest that the gene number may be somewhat higher. a. Why was it tempting to speculate that each band corresponds to a single gene? What does this suggest about the number of different proteins Drosophila can make? Does that seem like a reasonable number to you? b. Assuming all the nonrepeated DNA is uniformly distributed in the chromosomes, how much nonrepeated DNA (in base pairs) is there in average band?arrow_forwardThe wild-type (normal) fruit fly, Drosophila melanogaster, has straight wings and long bristles. Mutant strains have been isolated that have either curled wings or short bristles. The genes representing these two mutant traits are located on separate chromosomes. Carefully examine the data from the following five crosses shown below (running across both columns). (a) Identify each mutation as either dominant or recessive. In each case, indicate which crosses support your answer. (b) Assign gene symbols and, for each cross, determine the genotypes of the parents.arrow_forward
- Hemophilia A is caused by a sex-linked recessive gene in human and in dogs. a. What proportions (and sexes), among their offspring will be hemophiliacs if a hemophilic male is mated to a homozygous nonhemophilic female?b. If a daughter produced by the mating in (a) is mated to a normal male, what proportions and (sexes) will be hemophilic among their offspring?arrow_forwardA rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C. If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?arrow_forwardLeber Congenital Amaurosis (LCA) causes progressive vision loss due to defects in the gene that encodes RPE65 isomerase. Affected individuals are homozygous recessive for mutant alleles of the RPE65 gene. You are trying to determine the molecular nature of the mutations in three individuals with LCA. For ease of analysis, you may assume that each individual is homozygous for the same mutant allele (though the three individuals have different mutations than each other). You use the polymerase chain reaction to amplify DNA from each patient and you determine the sequence of the DNA and compare it to unaffected individuals. You identify the following differences. Note that the non-template strand of DNA is given and the changes are highlighted using red boldface. You can assume that the sequences are in the first reading frame (eg. the first three nucleotides of each sequence is a codon). The coding region of the gene is 1602 bp and the position of the sequences shown below is…arrow_forward
- Not all inherited traits are determined by nuclear genes (i.e., genes located in the cell nucleus) that are expressed during the life of an individual. In particular, maternal effect genes and mitochondrial DNA are notable exceptions. With these ideas in mind, let’s consider the cloning of a sheep (e.g., Dolly). A. With regard to maternal effect genes, is the phenotype of such a cloned animal determined by the animal that donated the enucleatedegg or by the animal that donated the somatic cell nucleus? Explain.arrow_forwardWhen a female melanotic fly is crossed with a normal male, the progeny are produced: 123 normal females, 125 melanotic females, and 124 normal males. In subsequent crosses between melanotic females and normal males, melanotic females are frequently obtained, but never any melanotic males. Provide a possible explanation for the inhertiacne of the melanotic mutation (Hint: The cross produces twice as many female progeny as male progeny)arrow_forwardA complex biochemical pathway is shown below, along with the alleles that either promote or inhibit each step of the pathway leading to a phenotype. Gene A has alleles A and a, B has alleles B and b, and so forth. Genes B and C are duplicate dominant epistatic lethal as heterozygotes (i.e. Bb Cc are lethal). Genes D and E are duplicate dominant epistatic (i.e. dd eg = desired phenotype). If I were to cross AA Bb cc Dd Ee with aa BB Cc Dd e, (i) (ii) What proportion of all offspring don't show the phenotype? What proportion of offspring survive? Gene A Gene B B Gene D a Gene C Gene Earrow_forward
- Some sweet-pea plants have purple flowers and others have white flowers. A homozygous variety of sweet pea that has purple flowers is crossed with a homozygous variety that has white flowers. All the F1have purple flowers. When these F1 self-fertilize, the F2 appear in a ratio of 916 purple to 716 white. a.Draw a hypothetical biochemical pathway to explain the production of purple and white flowers in sweet peas.arrow_forwardAPOE gene has been found to be a major contributor to sporadic Alzheimer's disease (AD), by acting as an age-of-onset modifier for the common relatively late-onset forms of the disease. Among four alleles causing early onset of AD, the epsilon4 allele (APOE4) disrupts this function. If you generate transgenic monkeys in which the normal allele of APOE gene is knocked out, what phenotype will you expect for those knockout monkeys? A. The APE mRNA expression will be completely suppressed. B. They slow down the development of AD. C. They develop AD early. D. They don't show any AD symptom.arrow_forwardWhile studying the genetics of the "Cute Faced Bat" face structure gene, three alleles ) are identified that produce 6 genotypes and 4 phenotypes “Cute”, “Super Cute Nose”, “Super Cute Face”, and “Super, Duper Cute” (equally expressing both Super Cute Face and Super Cute Nose). Given these observations, what can you conclude about the allele interactions?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY