Chapter10: Skin Deep
Section: Chapter Questions
Problem 1CTE
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Topic Video
Question
An experimental assay for the blood-clotting protein called factor
IX is available. A blood sample was obtained from each individual in the following pedigree. The amount of factor IX protein, shown within each symbol on the pedigree, is expressed as a percentage of the average amount observed in individuals who do not carry a mutant copy of the gene.
Transcribed Image Text:98
51
I-1
I-2
95
49
<1
102
44
107
II-1
П-2
П-3
Il-4
П-5
Il-6
(52
Ш-5
44
<l
98
94
97
59
98
Ш-1
III-2
III-3
Ш-4
III-5
Ш-6
Ш-7
Ш1-8
97
IV-2
(108
(102)
<l
97
IV-1
IV-3
IV-4
IV-5
What is the likely genotype of each person in this pedigree?
Expert Solution
Step 1
Factor IX is a blood clotting protein, which belongs to the family of peptidase Sl. It was found in 1952; the lacking of this protein causes the disease hemophilia (continuous bleeding without coagulation). It is also known as the Christmas disease. It helps in making clots whenever bleeding occurs in the body to control the overflow of the bleeding.
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