Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 3, Problem 18P
People heterozygous for normal and nonfunctional mutant alleles of the SMARCAD1 gene have a condition known as adermatoglyphia: they have no fingerprints. Sometime adermatoglyphia is called immigration delay disease because people lacking fingerprints have trouble obtaining passports.
Homozygote for nonfunctional mutant alleles do not exist –they are never born. Describe the dominance relation between the mutant and wild-type alleles of SMARCAD1.
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Chapter 3 Solutions
Genetics: From Genes to Genomes
Ch. 3 - For each of the terms in the left column, choose...Ch. 3 - In four-oclocks, the allele for red flowers is...Ch. 3 - The Aa heterozygous snapdragons in Fig. 3.3 are...Ch. 3 - Recall from Chapter 2 Fig. 2.20 that Mendels R...Ch. 3 - In the fruit fly Drosophila melanogaster, very...Ch. 3 - A cross between two plants that both have yellow...Ch. 3 - In radishes, color and shape are each controlled...Ch. 3 - A wild legume with white flowers and long pods is...Ch. 3 - Assuming no involvement of the Bombay phenotype in...Ch. 3 - Several genes in humans in addition to the ABO...
Ch. 3 - Alleles of the gene that determines seed coat...Ch. 3 - One of your fellow students tells you that there...Ch. 3 - In a population of rabbits, you find three...Ch. 3 - In clover plants, the pattern on the leaves is...Ch. 3 - Fruit flies with one allele for curly wings Cy and...Ch. 3 - In certain plant species such as tomatoes and...Ch. 3 - In a species of tropical fish, a colorful orange...Ch. 3 - People heterozygous for normal and nonfunctional...Ch. 3 - Using old Fugate family Bibles and the Perry...Ch. 3 - A rooster with a particular comb morphology called...Ch. 3 - A black mare was crossed to a chestnut stallion...Ch. 3 - Filled-in symbols in the pedigree that follows...Ch. 3 - You perform a cross between two true-breeding...Ch. 3 - a. How would you describe inheritance of flower...Ch. 3 - Suppose the intermediate called Colorless...Ch. 3 - Explain the difference between epistasis and...Ch. 3 - The dominant allele H reduces the number of body...Ch. 3 - Secretors genotypes SS and Ss secrete their A and...Ch. 3 - Normally, wild violets have yellow petals with...Ch. 3 - A woman who is blood type B has a child whose...Ch. 3 - The following table shows the responses of blood...Ch. 3 - Three different pure-breeding strains of corn that...Ch. 3 - In mice, the AY allele of the agouti gene is a...Ch. 3 - A student whose hobby was fishing pulled a very...Ch. 3 - Suppose that blue flower color in a plant species...Ch. 3 - This problem examines possible biochemical...Ch. 3 - Considering your answers to Problem 36, does the...Ch. 3 - You picked up two mice one female and one male...Ch. 3 - Figure 3.21 and Fig. 3.28b both show traits that...Ch. 3 - Three genes in fruit flies affect a particular...Ch. 3 - The garden flower Salpiglossis sinuata painted...Ch. 3 - In foxgloves, three different petal phenotypes...Ch. 3 - In a culture of fruit flies, matings between any...Ch. 3 - Prob. 44PCh. 3 - A couple wants to know the probability that their...Ch. 3 - This problem illustrates why classical geneticists...Ch. 3 - Prob. 47PCh. 3 - Familial hypercholesterolemia FH is an inherited...Ch. 3 - You have come into contact with two unrelated...Ch. 3 - Polycystic kidney disease is a dominant trait that...Ch. 3 - Identical monozygotic twins have similar, but not...Ch. 3 - Using each of the seven coat color genes discussed...
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- One particularly useful feature of the Hardy-Weinberg equation is that it allows us to estimate the frequency of heterozygotes for recessive genetic diseases, assuming that Hardy-Weinberg equilibrium exists. As an example, let’s consider cystic fibrosis, which is a human genetic disease involving a gene that encodes a chloride transporter. Persons with this disorder have an irregularity in salt and water balance. One of the symptoms is thick mucus in the lungs that can contribute to repeated lung infections. In populations of Northern European descent, the frequency of affected individuals is approximately 1 in 2500. Because this is a recessive disorder, affected individuals are homozygotes. Assuming that the population is in Hardy-Weinberg equilibrium, what is the frequency of individuals who are heterozygous carriers?arrow_forwardIn mice, the A allele causes agouti fur, the AY allele causes yellow fur and is dominant to the A allele. The homozygous AY AY genotype is lethal. Why is the AYAY homozygous condition lethal? The AY allele highly transcribes the merc gene which is lethal in a homozygous AYAY individual. None of the other answers are correct. The AY allele lacks an upstream merc gene which is required for normal embryonic development. The AY allele contains a null mutation in the A gene, which is required for normal embryonic development. The yellow pigment produced by A allele is required for survival.arrow_forwardThe correct answer is : codominance and incomplete penetrance because in codominance, heterozygotes express both alleles equally, so heterozygotes will have two phenotypes, both visible. In incomplete penetrance, some individuals with a particular genotype have a phenotype that does not match their genotype. The ratio shown suggests that not all heterozygotes have the splotchy phenotype normally expected and instead have the dominant brown phenotype.arrow_forward
- Explain why most loss-of-function alleles (hypomorphic or amorphic) are recessive to wild-type alleles, but some are incompletely dominant or dominant.arrow_forwardWild-type mice have brown fur and short tails. Loss of function of a particular gene produces white fur, while loss of function of another gene produces long tails, and loss of function at a third locus produces agitated behavior. Each of these loss of function alleles is recessive. If a wild-type mouse is crossed with a triple mutant, and their F1 progeny is test-crossed, the following recombination frequencies are observed among their progeny. Produce a genetic map for these loci. Brown, short tailed, normal: 955 White, short tailed, normal: 16 Brown, short tailed, agitated: 0 White, short tailed, agitated: 36 Brown, long tailed, normal: White, long tailed, normal: Brown, long tailed, agitated: 46 0 14 White, long tailed, agitated: 933arrow_forwardYour internship with Dr. Nefario at Gru Industries is going well so far, but a recent mission to obtain a shrink ray requires a special kind of Minion. You identify that the ideal Minion phenotypes for this mission are two eyes, pale yellow, and short. From your previous work, you’ve found that:Two-eyed (D) is completely dominant over one-eyed (d)Yellow (Y) is incompletely dominant with white (y)Tall (T) is completely dominant over short (t) a. The only reproductive individuals you have at the moment (it was surprise mission!) are a true breeding two-eyed, yellow, short Minion and a one heterozygous for each trait. What genotypic ratios would you expect for this crossassuming that each locus is on a different chromosome? What total proportion would you expect to be the desired phenotype for the mission? b. The mission has since been delayed due to lack of financial support, so you’ve got some time. All the individuals from the F1 cross above are now reproductive. Which genotypes would…arrow_forward
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