Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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Chapter 3, Problem 3SQE
Using the Goldman-Hodgkin-Katz equation, determine what happens to the resting membrane potential if the ECF
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Use the Goldman Equation to calculate the resting membrane potential at 37°C for each case:
In the Nernst equation [V = 62 log10 (Co/ Ci)], the term Co represents:
the intracellular concentration of calcium
the extracellular concentration of potassium
the extracellular concentration of sodium
the intracellular concentration of potassium
the membrane potential (in millivolts)
In the Nernst equation [V = 62 log10 (Co/ Ci)], the term Co represents:
the intracellular concentration of potassium
the intracellular concentration of chloride
the membrane potential (in millivolts)
the extracellular concentration of sodium
the extracellular concentration of potassium
Chapter 3 Solutions
Human Physiology: From Cells to Systems (MindTap Course List)
Ch. 3.1 - Draw how phospholipid molecules align themselves...Ch. 3.1 - Prob. 2CYUCh. 3.1 - Prob. 3CYUCh. 3.2 - Prob. 1CYUCh. 3.2 - Prob. 2CYUCh. 3.2 - Prob. 3CYUCh. 3.3 - Prob. 1CYUCh. 3.3 - Distinguish between passive and active forces that...Ch. 3.4 - List the means of unassisted membrane transport.Ch. 3.4 - Prob. 2CYU
Ch. 3.4 - Prob. 3CYUCh. 3.5 - Draw a graph comparing simple diffusion down a...Ch. 3.5 - Describe what causes the carrier to change shape...Ch. 3.5 - Distinguish between symport and antiport.Ch. 3.6 - Prob. 1CYUCh. 3.6 - Describe the relative contributions of k+ and Na+...Ch. 3.6 - Prob. 3CYUCh. 3 - The nonpolar tails of the phospholipid molecules...Ch. 3 - Prob. 2RECh. 3 - Prob. 3RECh. 3 - At resting membrane potential, there is a slight...Ch. 3 - Using the answer code on the right, indicate which...Ch. 3 - Prob. 6RECh. 3 - Prob. 7RECh. 3 - Prob. 1UCCh. 3 - Prob. 2UCCh. 3 - What two properties of a particle influence...Ch. 3 - Prob. 4UCCh. 3 - Prob. 5UCCh. 3 - Prob. 6UCCh. 3 - Describe the contribution of each of the following...Ch. 3 - Using the Nernst equation, calculate the...Ch. 3 - One of the important uses of the Nernst equation...Ch. 3 - Using the Goldman-Hodgkin-Katz equation, determine...Ch. 3 - When William H. was helping victims after a...Ch. 3 - Which of the following methods of transport is...Ch. 3 - Assume that a membrane permeable to Na+ but not to...Ch. 3 - A solution may have the same osmolarity as normal...Ch. 3 - Prob. 4TAHLCh. 3 - Prob. 5TAHL
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- Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACEACE), which cleaves the blood-pressure regulating peptide angiotensin I. ACEACE has a KM=52KM=52 μMμM for angiotensin I, which is present in plasma at a concentration of 75 μMμM. When enalaprilat is present at 2.4 nMnM, the activity of ACE in plasma is 14 %% of its uninhibited activity. What is the value of KIKI for enalaprilat?arrow_forwardThe membrane separating compartments A and B of the following chamber is permeable to Cl- ions (gCl = 5) but impermeable to water and K+. The initial concentrations of KCl in compartments A and B, before diffusion has occurred, are presented below. Use this information to answer questions 9-12. Note: Whenever necessary, consider compartment A as the ICF and compartment B as the ECF. KCl = 10 mM A KCl = 150 mM B 9. After equilibrium, the potential of compartment A will be _____mV (include polarity) compared to a reference of 0 mV. Consider compartment B as the outside. A) -70 mV B) 70 mV C) -90 mV D) 90 mV 10. At equilibrium, the flux of Cl- from compartment A to compartment B will be ______ the flux of Cl- from compartment B to compartment A. A) equal to B) less than C) more than 11. Increasing the concentration of [Cl-] in compartment B from 150 mM to 200 mM will ______________. A) make ECl more positive B) make EK more negative C) make ECl more negative D) not change the value of ECl…arrow_forwardDescribe the normal functioning of the Na-K pump, with special attention on how phosphorylation state affects ion binding affinity.arrow_forward
- By how much, and in which direction, will EK be altered by (a) halving and (b) multiplying by five the concentration of K+ in the saline?arrow_forwardWith regard to fluid movement between body fluid compartments, what effect does oral/parenteral administration of a hypotonic NaCl solution (0.45% NaCl, 145 mOsm/kg) have on the volume & osmolality of the extracellular fluid compartment (ECF), and on the volume & osmolality of the intracellular fluid compartment (ICF)? Clearly explain your reasoningarrow_forwardConsider the effect of a twofold increase in the ECF concentration of Na+ or K+ ions. Which increase in ion concentration is the more deadly and why?arrow_forward
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