(a) Interpretation: The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined. The reason for the surprising results should be determined. Concept introduction: Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 1

Question

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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True or False. Explain. A) At no time during protein synthesis does an amino acid make direct contact with the mRNA being translated. B) Because the two strands of DNA are complementary, the mRNA of a gene can be synthesized using either strand as a template.

AAAGAGAAAAGAAUA to AAAGAGAAAUGAAUA. Suppose the codon sequence has a single base pair mutation If the old protein sequence was Lys-Glu-Lys-Arg-Ile, what will be the new sequence encoded by the mutant gene? (Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Leu-Pro.) Submit Answer Retry Entire Group No more group attempts remain

An extra piece. In one type of mutation leading to a form of thalassemia, the mutation of a single base (G to A) generates a new 3' 3' splice site (blue in the illustration below) akin to the normal one (yellow) but farther upstream. Normal 3' end of intron 5' CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3' 5' CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3' What is the amino acid sequence of the extra segment of protein synthesized in a thalassemic patient having a mutation leading to aberrant splicing? The reading frame after the splice site begins with TCT.

Answer 2

Question

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 3

Question

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 4

Question

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

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Answer 5

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 6

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 7

Chapter 26, Problem 44P

Interpretation Introduction

(a)

Interpretation:

The results of graph A about the catalytic activity of the enzyme from the GD cells should be determined.

The reason for the surprising results should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 8

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 9

Interpretation Introduction

(b)

Interpretation:

Two possible explanations for the figure B should be determined.

The reason to ensure that the extracts have the same number of cells should be determined.

The purpose for including the western blot for actin should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 10

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 11

Interpretation Introduction

(c)

Interpretation:

If the amount of mRNA in both the cells is equal, then the results in figure B should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), the enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The nature of defect in GD enzyme should be determined.

The significance of the increase in activity of the enzyme from the normal cell observed in the presence of the inhibitor should be determined.

Concept introduction:

Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase), an enzyme that degrades glucocerebrosides. This disease is the most common lysosomal disease in humans. The most common symptoms of Gaucher disease is bone pain, fatigue, enlarged liver, and cognitive disabilities.

Answer 14

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Answer 15

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Answer 16

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Answer 17

Ch. 26 - Prob. 1P Ch. 26 - Prob. 2P Ch. 26 - Prob. 3P Ch. 26 - Prob. 4P Ch. 26 - Prob. 5P Ch. 26 - Prob. 6P Ch. 26 - Prob. 7P Ch. 26 - Prob. 8P Ch. 26 - Prob. 9P Ch. 26 - Prob. 10P

Solution Summary: The author explains that Gaucher disease is caused due to the mutation in the gene that encodes glucocerebrosidase (GCase).

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