Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 26, Problem 42P
Interpretation Introduction
Interpretation:
The reason for the production of cholesterol depends on the ATP- citrate lyase activity should be determined.
Concept introduction:
Cholesterol is a type of steroid. The steps for the biosynthesis of cholesterol are the formation of isoprene units, squalene formation and the cyclization of squalene.
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Instructions.
Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described.
Name: citryl-CoA synthetase
Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
Name: D-xylulose reductase
Reaction: xylitol + NAD+ = D-xylulose + NADH + H+
Name: cellobiose phosphorylase
Reaction: cellobiose phosphate = α-D-glucose 1-phosphate + D-glucose
Name: carbonic anhydrase
Reaction: H2CO3 = CO2 + H2O
Other info: The enzyme catalyzes the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH.
Name: pantoate activating enzyme
Reaction: ATP + (R)-pantoate = AMP + diphosphate + (R)-pantothenate.
G. ENZYME CLASSIFICATION.
Identify the main class of enzymes used to catalyzed the following reactions:
1. Lactate dehydrogenase:
NADH+H
NAD
HC-OH
CH3
CH
Pynnte
Lactate
2. Methylmalonyl-CoA mutase:
CH CH
SCOA
CH,CH,
SCOA
coenzyme B12
COO
COO
methylmalonyl-CoA
succinyl-CoA
3. Enolase:
0.
H–Ċ–0–P–0-
C-0–P-0- + H,0
HO–CH,
CH 6
Phosphoenolpyruvate
2-Phosphoglycerate
4. Chymotrypsin:
-0–CH,CH3 + H2O
- RCOOH + HOCH,CH3
5. Pyruvate carboxylase:
coo
• co, • ATP + H,0
H-C-H . ADP + P, + 2H
čoo
CH,
Pyruvate
Oxaleacetate
BIOCHEMISTRY. Could glycerol be used to regenerate the OAA for maintenance of TCA cycle activity? Yes or No? Explain.
Chapter 26 Solutions
Biochemistry
Ch. 26 - Prob. 1PCh. 26 - Prob. 2PCh. 26 - Prob. 3PCh. 26 - Prob. 4PCh. 26 - Prob. 5PCh. 26 - Prob. 6PCh. 26 - Prob. 7PCh. 26 - Prob. 8PCh. 26 - Prob. 9PCh. 26 - Prob. 10P
Ch. 26 - Prob. 11PCh. 26 - Prob. 12PCh. 26 - Prob. 13PCh. 26 - Prob. 14PCh. 26 - Prob. 15PCh. 26 - Prob. 16PCh. 26 - Prob. 17PCh. 26 - Prob. 18PCh. 26 - Prob. 19PCh. 26 - Prob. 20PCh. 26 - Prob. 21PCh. 26 - Prob. 22PCh. 26 - Prob. 23PCh. 26 - Prob. 24PCh. 26 - Prob. 25PCh. 26 - Prob. 26PCh. 26 - Prob. 27PCh. 26 - Prob. 28PCh. 26 - Prob. 29PCh. 26 - Prob. 30PCh. 26 - Prob. 31PCh. 26 - Prob. 32PCh. 26 - Prob. 33PCh. 26 - Prob. 34PCh. 26 - Prob. 35PCh. 26 - Prob. 36PCh. 26 - Prob. 37PCh. 26 - Prob. 38PCh. 26 - Prob. 39PCh. 26 - Prob. 40PCh. 26 - Prob. 41PCh. 26 - Prob. 42PCh. 26 - Prob. 43PCh. 26 - Prob. 44PCh. 26 - Prob. 45PCh. 26 - Prob. 46PCh. 26 - Prob. 47P
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