Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 24, Problem 20PDQ
Epigenetics is a relatively new area of genetics with a focus on phenomena that affect gene expression but do not affect DNA sequence. Epigenetic effects are quasi-stable and may be passed to progeny somatic or germ-line cells. What are known causes of epigenetic effects, and how do they relate to cancer?
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The use of embryonic stem cells has been proposed for replacing cells that are destroyed by disease or injury. Because of ethical concerns about creating and destroying embryos to produce embryonic stem cells, researchers have attempted to create induced pluripotent stem cells (iPSCs). In this chapter, we discussed studies showing that iPSCs retain some epigenetic marks from the differentiated adult cells from which they were derived. What implications might this research have for attempts to use iPSCs to regrow cells and tissues?
Epigenesis relating to genetics refers to which of the following
A.
Genetic information is limited to what we inherit only from our biological parents.
B.
Genes are not influenced by environmental factors.
C.
Genes we inherit are fully expressed at birth.
D.
Genes are turned on or off as needed, by the developing body or environmental triggers, across the life-span
Although each cell in your body contains the same set of genes, the genes that are “turned on” differ depending on the type of cell. What signals different genes to be “turned on” or transcribed in different cells?
What types of behaviours or environmental circumstances can lead to changes in an individual’s epigenome? Explain.
3. Explain how changes in your epigenome can alter the DNA of your future children before they are even born.
4.) Explain TWO implications of these findings for society. (Hint: think big! Implications for how disease is transmitted, intergenerational trauma, the cycle of poverty, etc.)
Chapter 24 Solutions
Concepts of Genetics (12th Edition)
Ch. 24 - Prob. 1NSTCh. 24 - People with a genetic condition known as...Ch. 24 - Prob. 3NSTCh. 24 - Cancer can arise spontaneously, but it can also be...Ch. 24 - Prob. 1CSCh. 24 - Prob. 2CSCh. 24 - If you agree to participate and then learn that...Ch. 24 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 24 - Prob. 2PDQCh. 24 - Where are the major regulatory points in the cell...
Ch. 24 - List the functions of kinases and cyclins, and...Ch. 24 - How can mutations in noncoding segments of DNA...Ch. 24 - What is the difference between saying that cancer...Ch. 24 - Prob. 7PDQCh. 24 - Prob. 8PDQCh. 24 - Define tumor-suppressor genes. Why is a mutated...Ch. 24 - Describe the steps by which the TP53 gene responds...Ch. 24 - Part of the Ras protein is associated with the...Ch. 24 - Prob. 12PDQCh. 24 - Distinguish between oncogenes and proto-oncogenes....Ch. 24 - Prob. 14PDQCh. 24 - How do translocations such as the Philadelphia...Ch. 24 - Explain why many oncogenic viruses contain genes...Ch. 24 - Prob. 17PDQCh. 24 - How do normal cells protect themselves from...Ch. 24 - Prob. 19PDQCh. 24 - Epigenetics is a relatively new area of genetics...Ch. 24 - Radiotherapy (treatment with ionizing radiation)...Ch. 24 - Genetic tests that detect mutations in the BRCA1...Ch. 24 - Explain the apparent paradox that both...Ch. 24 - As part of a cancer research project, you have...Ch. 24 - Mutations in tumor-suppressor genes are associated...Ch. 24 - Prob. 26ESPCh. 24 - Those who inherit a mutant allele of the RB1...Ch. 24 - The table in this problem summarizes some of the...Ch. 24 - Researchers have identified some tumors that have...Ch. 24 - Prob. 30ESP
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- Let’s suppose you were interested in developing drugs to preventepigenetic changes that may contribute to cancer. What cellularproteins would be the target of your drugs? What possible sideeffects might your drugs cause?arrow_forwardEpigenetics is a HUGE new field in understanding health factors that are transmitted from generation to generation beyond simple genetic inheritance. For example: epigenetic factors contribute to the onset of disease by triggering underlying genetic information. What do you think about that?arrow_forwardDefine Epigenetic changes. Are epigenetic changes the same thing as mutations? Explain why or why not.arrow_forward
- Acquired mutation in the p53 gene is the most common genetic alteration found in human cancer (> 50% of all cancers). A germline mutation in p53 is the causative lesion of Li- Fraumeni familial cancer syndrome. In many tumors, one p53 allele on chromosome 17p is deleted and the other is mutated. What type of protein is encoded by the p53 gene? (A) Caspase (B) DNA repair enzyme (C) Membrane cell adhesion molecule (D) Serine phosphatase (E) Telomerase (F) Transcription factor (G) Tyrosine kinasearrow_forwardDefine epigenetics. Are all epigenetic changes passed from parentto offspring? Explain.arrow_forwardSince all cells contain the same number of chromosomes and the overall same/similar genome how would the genome in a nerve cell work differently than the genome of a muscle cell? In other words what epigenetic processes cause these differences between cell types at the molecular levelarrow_forward
- Researchers have identified some tumors that have no recurrent mutations or deletions in known oncogenes or tumor-suppressor genes and no detectable epigenetic alterations. However, these tumors often have large chromosomal deletions. What are some possible explanations that could account for the genetic causes behind these tumors?arrow_forwardHeritable effects of gene expression that are not caused by a change in DNA sequence are called epigenic changes. What causes these changes?arrow_forwardIf you were to design an experiment to get p53 back into cancer cells, how would you go about that work? How would you direct p53 into the nucleus of cancer cells without directing it to the nucleus of healthy cells? As an overabundance of p53 in healthy cells would cause problems. Could someone in depth answer these questions for me and explain them cellularly.arrow_forward
- A gene, which we will call gene C, can be epigenetically modified in such a way that its expression in some cells is permanently silenced. Describe how you could conduct cell-fusion experiments to determine if a cis- or a trans-epigenetic mechanism is responsible for maintaining the silencing of gene C.arrow_forwardhttps://ny.pbslearningmedia.org/resource/biot09.sci.life.gen.epigenetics/epigenetics/ Explain DNA methylation. How does this process influence cellular function?arrow_forwardWhat are some good scientific expierment questions about stem cells to treat pediatric tumors and epigenetics? can you come up with some questions for that topicarrow_forward
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