Organic Chemistry (6th Edition)
Organic Chemistry (6th Edition)
6th Edition
ISBN: 9781260119107
Author: Janice Gorzynski Smith
Publisher: McGraw Hill Education
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Chapter 23.6, Problem 11P
Interpretation Introduction

Interpretation: Among the given amines, the amine which cannot be prepared by reduction of an amide is to be deteremined.

Concept Introduction: The synthesis of amine can be carried out by reduction of nitro compounds, nitriles and amides. Nitro compounds can be reduced to amines using catalytic hydrogenation or iron/palladium metal in presence of acid. Nitriles and amides are reduced to amines using lithium aluminium hydride.

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In general, amines are nucleophilic due to: Select one: a. Existence of negative charge in amine group b. Amines are more electronegative than other functional groups C. Lone pairs in the amine group available for donation d. None of the above
Which amines cannot be prepared by reduction of an amide?
The hydrolysis of an amide in acidic conditions forms       A. a carboxylate salt and an alcohol       B. a carboxylate salt and an amine       C. an alcohol and an amine salt (an ammonium ion)       D. a carboxylic acid and an amine salt (an ammonium ion)
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