Interpretation:
The peak concentration of the drug needs to be determined.
Concept introduction:
The drug concentration is defined as the amount of drug in given volume of the blood plasma which is measured in ng per mL.
Explanation of Solution
The peak concentration of the drug is the highest amount of drug which can be obtained in blood.
It is denoted as Cmax which is a pharmacokinetic measure and helps in determining the drug dosing. The peak level is highest drug concentration present in the blood of the patient.
The graph below shows the drug (beclomethasone) concentration after one dose in blood using the CFC or HFA propellant in the inhaler.
According to the given graph, the time taken by drug to reach its maximum concentration is 1 hour. For HFA, the highest concentration is 0.42 ng/mL approximately and for CFC, the value is 0.34 ng/mL.
Chapter 22 Solutions
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