Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 22, Problem 22.3CC
Drugs that affect the reuptake of neurotransmitters are in widespread use for the treatment of attention-deficit/hyperactivity disorder and clinical depression. In molecular terms, explain what effect(s) such reuptake inhibitors have on postsynaptic neurons, assuming that the neurotransmitter in question is excitatory for that postsynaptic neuron.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
True or false: Manipulating the synthesis of neurochemicals produces only short-term effects in most cases due to sensitive feedback loops for neurochemical production.
The one-way propagation of action potentials away from the original site of activation is ensured by the
thanks a lot in advance:)
Why neurotransmitters are important? Cite at least 3 examples.
Chapter 22 Solutions
Becker's World of the Cell (9th Edition)
Ch. 22 - Ouabain is an African plant derivative that has...Ch. 22 - You have isolated a toxin from a previously...Ch. 22 - The poison produced by some species of Central and...Ch. 22 - Drugs that affect the reuptake of...Ch. 22 - The Truth About Nerve Cells. For each of the...Ch. 22 - QUANTITATIVE The Resting Membrane Potential. The...Ch. 22 - QUANTITATIVE Patch Clamping. Patch-clamp...Ch. 22 - The Equilibrium Potential. Answer each of the...Ch. 22 - QUANTITATIVE Heart Throbs. An understanding of...Ch. 22 - The All-or-None Response of Membrane Excitation. A...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Excitatory neurotransmitters, example acetylcholine, effect firing of action potential. In contrast, inhibitory neurotransmitters, example, GABA suppresses firing of action potential. Based on your understanding of ion distribution across the membrane (more Na+ and Cl- outside; more K+ inside) and the mechanism of firing of an action potential, propose a molecular mechanism for the action of a tranquilizer drug -calming effect, example Valium. what is the most plausible mechanism for Valium and an alternative mechanism?arrow_forwardWhich statement(s) is/are true regarding the release of glutamate? (Select all that apply) Question 4 options: A) It acts by opening up Cl channels B) It can cause an EPSP in the postsynaptic membrane of a typical cortical neuron C) It can cause an EPSP in the postsynaptic membrane of a retinal neuron D) It can cause an IPSP in the postsynaptic membrane of a retinal neuronarrow_forwardDescribe the biochemical signaling steps by which activation of the NMDA receptor causes the postsynaptic cell to fire larger EPSPs.arrow_forward
- Changes in intracellular Ca2+ is one of the main governing factors that determines the direction of plasticity (i.e., whether a synapse potentiates or depresses). Provide a general mechanism to explain how changes in intracellular Ca2+ can result in either synaptic depression or synaptic potentiation (refer to our discussion on kinases and phosphatases).arrow_forwarda)The distribution of sodium ions across the cell membrane of a neuron is 20 mmol/L inside the cell and 200 mmol/L outside the cell. When the system reaches equilibrium, the concentration of sodium ions will be identical on both sides of the cell membrane. What is the standard Gibbs energy difference in the system? Assume the system is at body temperature (37 °C). b)What is the Gibbs energy difference across the membrane in the initial state (prior to reaching equilibrium)?arrow_forwardThe correlation between neurons can explain the basis of the synaptic modification, that is, how much they can connect to each other or if they are not synchronized, how much they can lose or weaken their connections. Draw a picture of an excitatory synapse such as glutamatergic with its receptors between the pre- and postsynaptic neuron.arrow_forward
- Buckeyium is a medication that binds to the NMDA receptor at the orthosteric binding site (were glutamate would normally bind). Assume glycine is already bonded and magnesium isn't inhibiting the NMDAR ion channel. Buckeyium would be regarded a poison if the channel did not open as a consequence of its binding.arrow_forwardLocal anesthetic is often used in dentistry to lessen the sensation of pain during dental procedures. It prevents propagation of nerve conduction by decreasing the flow of ions. a. Describe how depolarization of an action potential can be blocked by the use of local anesthetic. b. Your classmate explained that once the threshold potential has been reached, the inside charge of the neuron is more positive than the outside charge. Is she correct? Can you compare the inside charge to the outside charge in an axon treated with local anesthetic?arrow_forwardButaclamol is a potent antipsychotic that has been used clinically in the treatment of schizophrenia. How many asymmetric centers does it have?arrow_forward
- Describe how an action potential in a presynaptic neuron causes a) an excitatory postsynaptic potential; or b) an inhibitory postsynaptic potential in a postsynaptic neuronarrow_forwardserotonin,y-aminobutyric acid, and dopamine are derived from different amino acids by just one or a very few chemical steps. name one step that is shared in the derivation of all three neurotransmitters?arrow_forwardName one of the differences between neurotransmitters (non-peptides) and neuropeptides.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Nervous System - Get to know our nervous system a bit closer, how does it works? | Neurology; Author: FreeMedEducation;https://www.youtube.com/watch?v=6O-0CVAgaEM;License: Standard youtube license