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Which statement(s) is/are true regarding the release of glutamate? (Select all that apply)
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- Which one of the following is not a criterion for small neurotransmitter (NT) status? a) postsynaptic receptor sites b) it is isolated from the presynaptic cytoplasmic terminal c) predictable amount of its release d) evidence of mechanism for inactivation and termination of its biological activityCalcium entry through NNDA receptor can potentiate synaptic transmission through the following mechanisms EXCEPT: a.) Insertion of AMPA receptors to postsynaptic membrane b.) Synthesis of NO to increase presynaptic transmitter release c.) Phosphorylation of AMPA receptors d.) Slowing down glutamate reupdate, so it remains longer in the synapseQuestion 23) For these three situations below, describe whether there are changes in humoral, viscero-motor, and somatic motor responses. If there are changes, describe them. A) A mouse mutant or MC4 receptors in the hypothalamic lateral area do not bind to alpha-MSH peptide B) A mutant mouse or MC4 receptors in the hypothalamic paraventricular nucleus does not bind to alpha-MSH peptide C) A mutant mouse or the alpha-MSH neurons do not synthesize alpha-MSH
- Let’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron. A) What type of summation of PSPs is this? Why? B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)Clostridium tetani toxin blocks the exocytosis of GABA. A. What anatomical part of a pre-synaptic neuron would be affected by this? B. How would a post-synaptic neuron’s likelihood of experiencing an action potential be affected by this toxin? C. Explain, using at least TWO of the following terms: threshold, depolarization, repolarization, hyperpolarization, summation, IPSP, EPSP, exocytosisAssume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.
- Read the following statements (a) The resting nerve membrane is freely permeable to Na*, K* ions and negatively charged proteins. (b) The activity of Na* - K* pump is responsible for maintaining resting membrane potential. (c) The resting membrane is impermeable to negatively charged proteins present in the axoplasm. Choose the option representing correct statements. b only a and b b and c a, b and cSelect the best answer or answers from the choices given: Inhibition of acetylcholinesterase by poisoning blocks neurotransmission at the neuromuscular junction because (a) ACh is no longer released by the presynaptic terminal, (b) ACh synthesis in the presynaptic terminal is blocked, (c) ACh is not degraded, hence prolonged depolarization is enforced onthe postsynaptic cell, (d) ACh is blocked from attaching to the postsynaptic ACh receptors.Local anesthetic is often used in dentistry to lessen the sensation of pain during dental procedures. It prevents propagation of nerve conduction by decreasing the flow of ions. a. Describe how depolarization of an action potential can be blocked by the use of local anesthetic. b. Your classmate explained that once the threshold potential has been reached, the inside charge of the neuron is more positive than the outside charge. Is she correct? Can you compare the inside charge to the outside charge in an axon treated with local anesthetic?
- Both rhodopsin in vision and the muscarinic acetylcholine receptor in cardiac muscle are coupled to ion channels via G proteins. Describe the similarities and differences between these two systems.John Hughes and Hans Kosterlitz identified the endorphin receptor in frogs, and concluded that animals have a "built in" opioid system. To make sure that endorphins are truly neurochemicals, which of the following question should we ask these gentlemen? Please select all that apply.a) Are endorphins released in response to presynaptic depolarization? b) Do endorphins interact with postsynaptic receptors? c) Are endorphins found in presynaptic cells? d) Are endorphins subject to reuptake?Which of the following is the role of axonal Calcium (Ca2+) channels in neuronal communication at the synapse? a) they inhibit the action potential causing it to stop b) Calcium channels have no role in this process c) by allowing calcium to exit the cell, they promote the propagation of action potential across the synapse by creating depolarization d) by blocking calcium entrance, they mediate the contraction of presynaptic axon to facilitate movement e) when they open, calcium enters the presynaptic terminal, promoting fusion of neurotransmitter vesicles with presynaptic membrane, and release of neurotransmitters to the synaptic cleft