Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 22, Problem 22.10PS
Down and Out. Endocannabinoids are produced by postsynaptic neurons but act on receptors (CB1 receptors) in presynaptic neurons. One type of neuron that is a target of endocannabinoids is glutamatergic neurons.
(a) CB1 agonists such as THC reduce calcium influx by blocking the activity of voltage-dependent calcium channels. What effect would this have on the release of glutamate?
(b) Glutamate causes the membrane of postsynaptic neurons to become hyperpolarized. How would THC be expected to affect the rate of nerve impulse transmission in postsynaptic neurons that make synapses with the glutamatergic neuron?
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Chapter 22 Solutions
Becker's World of the Cell (9th Edition)
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