Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 22, Problem 14PDQ
Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?
A1A1 = 30 A1A2 = 27 A2A2 = 12
A1A3 = 17 A2A3 = 10 A3A3 = 4
What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium.
A.
0.182
B.
0.27
C.
0.03
D.
0.317
E.
0.107
F.
0.09
Assume that the frequency of an allele that causes an autosomal recessive disease is 0.03. What is the probability of a person having the disease when his or her parents are unrelated (i.e., mating is random)? What is the probability of having the disease when the parents are first cousins? What about when the parents are second cousins?
The incidence of a rare autosomal recessive genetic disorder, Tay-Sachs, is approximately 1 in
3,500 in a certain population. Assuming that this population is in Hardy-Weinberg equilibrium,
what is the probability that a phenotypically normal female with no family history, and a
phenotypically normal male who had an affected great-aunt, will have a child who is a carrier for
Tay-Sachs?
Chapter 22 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 22 - CASE STUDY |An unexpected outcome A newborn...Ch. 22 - CASE STUDY |Anunexpected outcome A newborn...Ch. 22 - CASE STUDY|An unexpected outcome A newborn...Ch. 22 - HOW DO WE KNOW? Population geneticists study...Ch. 22 - Review the Chapter Concepts on page 441. All these...Ch. 22 -
3. Price et al. (1999. J. Bacteriol. 181:...Ch. 22 -
4. The genetic difference between two Drosophila...Ch. 22 - The use of nucleotide sequence data to measure...Ch. 22 - Calculate the frequencies of the AA, Aa, and aa...Ch. 22 - Prob. 7PDQ
Ch. 22 -
8. What must be assumed in order to validate the...Ch. 22 - In a population where only the total number of...Ch. 22 -
10. If 4 percent of a population in equilibrium...Ch. 22 -
11. Consider a population in which the frequency...Ch. 22 - If the initial allele frequencies are p = 0.5 and...Ch. 22 -
13. Under what circumstances might a lethal...Ch. 22 - Assume that a recessive autosomal disorder occurs...Ch. 22 -
15. One of the first Mendelian traits identified...Ch. 22 -
16. Describe how populations with substantial...Ch. 22 - Achondroplasia is a dominant trait that causes a...Ch. 22 -
18. A recent study examining the mutation rates...Ch. 22 - A form of dwarfism known as Ellis–van Creveld...Ch. 22 -
20. List the barriers that prevent interbreeding...Ch. 22 - What are the two groups of reproductive isolating...Ch. 22 - Prob. 22PDQCh. 22 -
23. In a recent study of cichlid fish inhabiting...Ch. 22 - What genetic changes take place during speciation?Ch. 22 - Some critics have warned that the use of gene...Ch. 22 - Comparisons of Neanderthal mitochondrial DNA with...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- In Sweden 1/500 are born with an autosomal recessive disorder called thalassemia. What is the carrier frequency within the population?arrow_forwardHelp me pleasearrow_forwardThe incidence of a rare autosomal recessive genetic disorder, Tay-Sachs, is approximately 1 in 3,500 in a certain population. Assuming that this population is in Hardy- Weinberg equilibrium, what is the probability that a phenotypically normal female with no family history, and a phenotypically normal male who had an affected great- aunt, will have a child who is a carrier for Tay-Sachs? O 1.96% O 9.99% O 0.28% O 0.03% O 2.2% O 0.14%arrow_forward
- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardThe cystic fibrosis allele is recessive. The frequency of cystic fibrosis is 0.000484, or about one in 2000 people. Calculate the allele frequencies. What portion of people are carriers (heterozygotes) for cystic fibrosis?arrow_forwardIn a population of Hopi indians the autosomal recessive gene for albinism exists at an allele frequency of 0.04. What proportion of these individuals are expected to be heterozygous?arrow_forward
- Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. Individuals with PKU have two recessive alleles and have very low levels of an enzyme that is needed to properly break down proteins. If a woman and her husband are both carriers and have three children, what is the probability of each of the following? Show your math. (Hint: You can represent your probabilities as fractions or decimals, but probabilities are always between 0 and 1) a. All three children are of normal phenotype. b. One or more of the three children have the disease. c.All three children have the disease.arrow_forwardCystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?arrow_forwardIf the frequency of those homozygous for a specific mutation that causes an autosomal monogenic recessive condition in a given population of 2 million individuals is 1/18900, how many individuals are likely to be carriers of the causative mutation? Please give your answer as a whole number.arrow_forward
- In a hypothetical population of 2500 people, 2275 people have brown eyes and 225 people have blue eyes (the homozygous-recessive phenotype). If there are 4000 children produced by this generation, how many (i.e., what number) of the children would be expected to be heterozygous for eye color?arrow_forwardUse the following information to answer the next question. Galactosemia is an autosomal recessive disorder. In this disorder, the digestive system is unable to digest the sugar galactose properly. It is a rare disorder that only one in about 30 000-50 000 Caucasian children in North America and Europe are born with. The frequency of the dominant allele in a population of 35 000 children, in which 1 is suffering from galactosemia, isarrow_forwardExcessive secretion of male sex hormones results in premature sexual maturation in males and masculization of the sex characters in females. This disorder is called the adrenogenital syndrome, and in Switzerland there is an autosomal recessive form of the disease that affects about one in 5000 newborns. a. Assuming random mating, what is the allele frequency of the recessive? b. What is the frequency of heterozygous carriers?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Immune System Diseases and Disorders; Author: Heather Davis;https://www.youtube.com/watch?v=3lIkxNv7MVI;License: Standard youtube license