Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Question
Chapter 21, Problem 8TYK
Summary Introduction
Introduction: Gene is the basic functional unit of heredity. A gene is a sequence of
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Students have asked these similar questions
You are studying celiacs disease and have identified a
potential gene for the disease using linkage analysis.
You decide to test your hypothesis by making
transgenic mice that carry a nonsense mutation in the
candidate gene you have identified to see if they
develop a phenotype similar to that found in Celiacs
disease
What sort or experimental approach are you using
when you test your gene in your mouse model?
a. Reverse genetic
b. Quantitative genetic
C. Forward genetic
D.Expression analysis
E. None of the above
Which of the following mutations would have the greatest negative impact on the protein product of a gene?
A.
a single base deletion close to the end of the coding region of a gene.
B.
a single base insertion near the start of the coding region of the gene
C.
a base-pair substitution
D.
a deletion of three bases near the middle of the gene
Identify the best match between the mutation description and term.
a.
Transversion: results in a change in single nucleotide from a purine to another purine or a pyrimidine to another pyrimidine
b.
Nonsense mutation: a change in the DNA that changes the codon code from one amino acid to another amino acid
c.
Missense mutation: causes a drastic change in phenotype because the change causes a premature stop in the amino acid sequence
d.
Indel: has the potential to cause large changes in transcription and subsequence amino acid sequence due to reading frameshifts
Chapter 21 Solutions
Study Guide for Campbell Biology
Ch. 21 - In what ways would third-generation sequencing be...Ch. 21 - Prob. 2IQCh. 21 - Refer to the organisms listed in Table 21.1 in...Ch. 21 - Explain why retrotransposons always move by the...Ch. 21 - For each of the following types of DNA sequences...Ch. 21 - Prob. 6IQCh. 21 - Prob. 7IQCh. 21 - If all Hox genes contain the same or very similar...Ch. 21 - About 25% of the human genome relates to the...Ch. 21 - Prob. 2SYK
Ch. 21 - Which of the following has decreased the time and...Ch. 21 - Prob. 2TYKCh. 21 - In the process called gene annotation, computer...Ch. 21 - Prob. 4TYKCh. 21 - Prob. 5TYKCh. 21 - Prob. 6TYKCh. 21 - What is a pseudogene? a. a gene that has been...Ch. 21 - Prob. 8TYKCh. 21 - Which of the following is common to both...Ch. 21 - Prob. 10TYKCh. 21 - Prob. 11TYKCh. 21 - Prob. 12TYKCh. 21 - Prob. 13TYKCh. 21 - Prob. 14TYKCh. 21 - Compared to genes in mice and chimpanzees, most...
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- Sickle cell disease is caused by a substitution in the beta globin gene. As a result, one amino acid is different in the mutant protein. Which of the following region is likely to be affected in the sickle cell allele? A. The promoter region B. The 5' UTR region C. The coding region D. The 3' UTRarrow_forwardA peptide is produced in two different cells. The primary structure is the same in both cells, but the amount of peptide is increased in one cell. What could be happening to the pre-mRNA or mRNA transcript within the cell that has the higher amount of this peptide? A. It has a shorter Poly-A tail B. An alternative polyadenylation (Poly-A) site is being selected C. Leaky scanning occurred D. B and C are both correct OE. None of the abovearrow_forwardIdentify the word or phrase that is the best match (some will remain blank). (Mouse Genome Informatics, GeneChip array, Confounding variable, 45,000, BLAST, 600, Aceview, BioGPS, SMART, minimize, 17, UCSC Genome Browser, External validity) A. Median number of copies of an mRNA in a cell B. Patterns and sizes of introns and exons C. H3K4me3 locations on chromosomes D. Each treatment given to a different litter of mice E. Find list of knockout mice for a gene D. Find similar proteins F. Random variation G. Tissue expression pattern of a gene H. The extent to which results can be extrapolatedarrow_forward
- The goal of most gene therapies is to insert a healthy copy of a gene into the genome. Besides CRISPR, techniques for integrating DNA into the genome do not target that DNA to a particular genomic location and thus different cells end up with the DNA sequence in different positions. B. The same gene integrated into different locations in the genome will be expressed differently. Why?arrow_forwarda. Which gene is mutated in individuals with sickle-cell anemia? b. What are the major symptoms of this disorder? c. What was the first published scientific description of sickle-cell anemia? d. Describe two other features of this disorder that you learned from the OMIM database and state where in the database you found this informationarrow_forwardAn individual with the genetic condition cystic fibrosis has CFTR protein with the amino acid histidine (at position 482), where the normal CFTR protein has arginine. No other changes are observed in the protein. This is the result of a ____ mutation. Select one: a. nonsense b. frameshift c. silent d. missensearrow_forward
- What is Sanger sequencing? Why do we use ddNTP? How to read a DNA sequence gel? c. What is a cDNA seq (RNA seq)? d. What is the main difference between a genomic and a transcriptome study?arrow_forwardHow can Cas9 technology be used in gene therapy. A. Base editing can be used to repair DNA error B. All 3 answers C. Cas9 can be used to activate transcription of a gene D. Knocking out a gene if it’s gain a function mutation is the cause of the diseasearrow_forwarda. The reading frame DNA sequence is: b. The mRNA sequence is: c. The polypeptide sequence is: A disease in frogs which causes their tongue to fall out of their mouths is killing the frog population in LA County. You obtain a dead frog and isolate its gene Xf. When you sequence this mutated gene, you find that the last ‘G’ at the end of the first line of this sequence has been deleted (i.e. the G at position 86). In order to determine how this mutation changes the resulting polypeptide, write the mutated polypeptide sequence in the space below. What kind of mutation was produced? The mutated polypeptide sequence is What kind of mutation was produced?arrow_forward
- All of the following are true about the design of the Beadle and Tatum experiment (one gene one polypeptide) EXCEPT: A. Used X-rays to generate auxotrophs B. Depended on the use of the bacteria, N. crassa C. Examined the way in which amino acid biosynthesis occurs D. Added nutrient intermediates to rescue lethal mutations included the study of conditional mutants E. Led to the one-gene-one polypeptide hypothesis.arrow_forwardWhich of the following is an RNA processing event that increases the number of potential polypeptides that can be encoded by a single gene. a. transcription b. alternative splicing c. alternative transcription d. polyadenylationarrow_forwardTautomerization: A. Causes frameshift insertions B. Causes frameshift deletions C. Results in permanent chemical changes in nitrogenous bases D. Cause transition mutations E. Cause transversion mutationsarrow_forward
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