Sickle cell disease is caused by a substitution in the beta globin gene. As a result, one amino acid is different in the mutant protein. Which of the following region is likely to be affected in the sickle cell allele?   A. The promoter region   B. The 5' UTR region   C. The coding region   D. The 3' UTR

Describe how a mutation in the regions below could cause such a drastic effect that it creates a“null allele.”a. Gene promoterb. Intronc. Exond. 3’-UTR

Differential RNA splicing may result in: a. A shift in the ratio of mRNA produced from two neighboring genes b. Inversion of exons in the mature mRNA c. Production of the same protein from two different genes d. Production of two different proteins with different properties from a single gene

Given a mutation in the promoter, coding region, and/or non-coding region of a gene, explain how these three scenarios create new alleles of the same gene.

What did the Hershey / Chase experiments (above) demonstrate about the molecules responsible for genetic inheritance patterns in the T2 bacteriophage? A. the genetic material consists of carbohydrates, not RNA B. the genetic material consists of protein, not lipids C. the genetic material consists of DNA, not polypeptides D. the genetic material consists of protein, not DNA E. the genetic material consists of lipids, not polypeptides

The promoter consensus sequence at the -10 BOX in the bio gene in E. coli was TAGACT; however, a transversion occurred which changed the G nucleotide to T, what outcome(s) are likely?   a. transcription levels would decrease because the promoter would be weaker   b. nothing would happen because the promoter would not change the mRNA sequence   c. the mutation would block RNA polymerase from binding to the DNA   d. transcription levels would increase because the promoter would be stronger   e. the bio gene does not require a functional promoter