Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Question
Chapter 2, Problem 51P
Summary Introduction
To review:
Genetic testing for human hereditary conditions for identification of heterozygous carriers.
Introduction:
Genetic testing for the heterozygous carrier is a practice of detecting the people for the possibility of conceiving progenies affected by recessive diseases. The recessive inheritance is characterized by one having the disease receiving two mutated copies of alleles- one from the mother and another from the father. The heterozygotes for the disease generally are carriers for the disease. The genetic testing of human hereditary conditions for identification of heterozygous carriers helps a couple before conception to decide the possible preventive measures, genetic diagnosis, or early prenatal diagnostic testing.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Match the following :
Genetic testing
Genetic screening
Genetic screening programs
Genetic screening opportunities
A test with high senstivity
A test with high specificity
predictive tests
Pre- symptomatic tests
Pre dispositional test
involves testing individuals for the genetic change underlying a condition for which there is no evidence.
can show that an individual is more likely than others to develop a specified condition.
indicate the presence of a causative genotype but the onset of signs and symptoms is not certain.
are offered as part of our public health service.
do not include conditions that show incomplete penetrance.
is performed cases where the onset of signs and symptoms is considered inevitable.
involves testing individuals for the genetic change underlying a condition for which there is evidence.
has a low false positive rate
has a low false negative rate
Answer in less than 30 words:Why are mathematical /statistical tools needed in the understanding of the transmission of traits in the field of Genetics?
Write brief summaries (no longer than three lines) on each of the following topics:(what/why/advantage(s)/disadvantage(s)) Manchester-specific markers
Chapter 2 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 2 -
1. Compare and contrast the following terms:
a....Ch. 2 - For the cross , what is the expected genotype...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - In mice, black coat color is dominant to white...Ch. 2 - Two parents plan to have three children. What is...Ch. 2 - Consider the cross AaBbCCAABbCc. a. How many...Ch. 2 - If a chi-square test produces a chi-square value...Ch. 2 -
8. Determine whether the statements below are...Ch. 2 - In the datura plant, purple flower color is...Ch. 2 - 10. The dorsal pigment pattern of frogs can be...
Ch. 2 - 11. Black skin color is dominant to pink skin...Ch. 2 - A male mouse with brown fur color is mated to two...Ch. 2 - 13. Figure 2.12 shows the results of Mendel’s...Ch. 2 - 14. An experienced goldfish breeder receives two...Ch. 2 -
15. The accompanying pedigree shows the...Ch. 2 -
16. A geneticist crosses a pure-breeding strain...Ch. 2 - Suppose an F1 plant from Problem 16 is crossed to...Ch. 2 - 18. In pea plants, the appearance of flowers along...Ch. 2 - 19. If two six-sided dice are rolled, what is the...Ch. 2 - Experimental Insight 2.1 describes data, collected...Ch. 2 -
21. The accompanying pedigree shows the...Ch. 2 - 22. The seeds in bush bean pods are each the...Ch. 2 - List all the different gametes that are possible...Ch. 2 - Organisms with the genotypes AABbCcDd and AaBbCcDd...Ch. 2 - 25. Blue moon beans produce beans that are either...Ch. 2 - In the fruit fly Drosophila, a rudimentary wing...Ch. 2 - In pea plants, plant height, seed shape, and seed...Ch. 2 - A variety of pea plant called Blue Persian...Ch. 2 - 29. In tomato plants, the production of red fruit...Ch. 2 - A male and a female are each heterozygous for both...Ch. 2 - A woman expressing a dominant phenotype is...Ch. 2 - Two parents who are each known to be carriers of...Ch. 2 - 33. An organism having the genotype AaBbCcDdEe is...Ch. 2 - 34. A man and a woman are each heterozygous...Ch. 2 - For a single dice roll, there is a 16 chance that...Ch. 2 - You have four guinea pigs for a genetic study. One...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - Sweet yellow tomatoes with a pear shape bring a...Ch. 2 - A cross between a spicy variety of Capsicum annum...Ch. 2 - Alkaptonuria is an infrequent autosomal recessive...Ch. 2 - 41. Humans vary in many ways from one another....Ch. 2 - 42. In chickens, the presence of feathers on the...Ch. 2 -
43. A pure-breeding fruit fly with the...Ch. 2 - 44. Situs inversus is a congenital condition in...Ch. 2 - 45. Domestic dogs evolved from ancestral grey...Ch. 2 - Alleles of the IGF-1 gene in dogs, encoding...Ch. 2 - 47. The accompanying pedigree shows a family in...Ch. 2 -
48. A pea plant that has the genotype RrGgwwdd is...Ch. 2 - Go to the OMIM website...Ch. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 -
52. In humans, the ability to bend the thumb...
Knowledge Booster
Similar questions
- Which of the following statements about Mendelian or complex disease is TRUE? Question options: Genetic methods for studying Mendelian phenotypes, such as crossing, is not useful for mapping quantitative trait loci. Mapping of quantitative trait loci does relies on genetic variations that directly contribute to the trait of interest. Both Mendelian and complex traits are associated with single gene locus. Genetic factors determine Mendelian traits, while environmental factors determine complex traits. Genome-wide association studies rely on polymorphic markers that are in linkage disequilibrium with alleles that contribute to the trait of interest.arrow_forwardA prospective groom, who is unaffected, has a sister with cystic fibrosis (CF), an autosomal recessive disease. Their parents are normal. The brother plans to marry a woman who has no history of CF in her family. What is the probability that they will produce a CF child? They are both Caucasian, and the overall frequency of CF in the Caucasian population is 1/2500—that is, 1 affected child per 2500. (Assume the population meets the Hardy– Weinberg assumptions.)arrow_forwardIn a paternity suit, a woman with type O blood claims that a man with type AB blood is the father of her type O baby. List the genetypes of the mom, man, and baby. Can the woman prove he is the father or can he is not? Why or why not? If the accused man was type A insyead of type AB, what would be his possible genotypes? Could the woman prove he is the father? Can the man prove he is not the father? Why or why not?arrow_forward
- A prospective groom, who is normal, has a sister with cystic fibrosis (CF), an autosomal recessive disease. Their parents are normal. The brother plans to marry a woman who has no history of CF in her family. What is the probability that they will produce a CF child? They are both Caucasian, and the overall frequency of CF in the Caucasian population is 1/2500—that is, 1 affected child per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)arrow_forwardTuberous Sclerosis (TS) is an autosomal dominant genetic disease characterized by seizures, mental retardation, autism, and benign tumors of the brain, heart, skin, and kidneys. The kidney tumors can also be malignant. This disease exhibits a wide range of severity, and only about 1/3 of the cases are inherited. Two different genes have been tightly linked to the disease in families where it is inherited. The remaining 2/3 appear to be due to mutations in one of the 2 genes as well. Overall it appears that 1/2 are caused by mutations in TSC1 and the other half by mutations in TSC2. A rat model for hereditary renal carcinoma (kidney cancer) has been found. Southern and Northern blot analysis of the TSC1 and TSC2 gene revealed no differences between these rats and normal rats. Not all the rats in the strain would get cancer but a significant proportion did and those were selected for and used in experiments. 1. a) What was detected by the Southern blots? (look this up, make your…arrow_forwardHemophilia is inherited as a sex-linked recessive trait. A non-hemophilic man marries a non-hemophilic woman whose father had hemophilia. With respect to this information, indicate all possible genotypes their children could possibly have. Show ALL work using punnett squares.arrow_forward
- Note there are no cells on this panel that have a double dose (homozygous) of the K antigen. Which of the following statements is true regarding the K+k- phenotype? Question 6 options: A) The phenotype is rare due to the high prevalence of the k antigen in the population. B) The phenotype is uncommon but does occur in about 10% of the population. C) The phenotype occurs in about 50% of the population. D) Although the phenotype is not represented on this antibody panel, it is fairly common in the population.arrow_forwardprovide an example of a clinical scenario where a Type A patient has wild type A alleles at the ABO gene, yet appears to be a weak A subgrouparrow_forwardA homozygous recessive allele, aa, is responsible for albinism. Humans can exhibit this phenotype. In each of the following cases, determine the possible genotypes of the mother and father, and of their children: (a) Both parents have normal phenotypes; some of their children are albino and others are unaffected: (b) Both parents are albino and have only albino children: (c) The woman is unaffected, the man is albino, and they have one albino child and three unaffected children: at a busy hospital. The son of the first couple has hemophilia, a recessive, X-linked Two mothers give birth to sor disease. Neither parent from couple #1 has the disease. The second couple has an unaffected son, despite the fact that the father has hemophilia. The two couples challenge the hospital in court, claiming their babies must have beer swapped at birth. You must advise as to whether or not the sons could have been swapped. What would you say? 5. In a dispute over parentage, the mother of a child with…arrow_forward
- Gaucher disease is an early onset rare autosomal recessively inherited lysosomal storage disorder (LSD). An adult woman who has no symptoms but has two affected brothers is referred for genetic counselling. Which of the following is correct? Oa. Before any carrier testing is carried out the woman can be correctly informed that the probability that her first son will be affected is 1 in 4. b. With two affected brothers the probability of her being a carrier is 1. Oc. If she is a carrier then the probability that each of her sons and each of her daughters will be affected is 1 in 4. d. The probability that she is a carrier is 1/2 Oe. The probability that she is a carrier is 2/3.arrow_forwardPedigree 1: What is the most likely mode of inheritance of this disease given its pattern on the pedigree? Autosomal Dominant Autosomal Recessive O X-Linked Dominant O X-Linked Recessivearrow_forwardBelow in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education