Which of the following statements about Mendelian or complex disease is TRUE? Question options: Genetic methods for studying Mendelian phenotypes, such as crossing, is not useful for mapping quantitative trait loci. Mapping of quantitative trait loci does relies on genetic variations that directly contribute to the trait of interest. Both Mendelian and complex traits are associated with single gene locus. Genetic factors determine Mendelian traits, while environmental factors determine complex traits. Genome-wide association studies rely on polymorphic markers that are in linkage disequilibrium with alleles that contribute to the trait of interest.
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
Which of the following statements about Mendelian or complex disease is TRUE?
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Genetic methods for studying Mendelian |
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Mapping of quantitative trait loci does relies on |
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Both Mendelian and complex traits are associated with single gene locus. |
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Genetic factors determine Mendelian traits, while environmental factors determine complex traits. |
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Genome-wide association studies rely on polymorphic markers that are in linkage disequilibrium with alleles that contribute to the trait of interest. |
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