Human Biology: Concepts and Current Issues (8th Edition)
Human Biology: Concepts and Current Issues (8th Edition)
8th Edition
ISBN: 9780134042435
Author: Michael D. Johnson
Publisher: PEARSON
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Chapter 19, Problem 4AWK

Geneticists often study patterns of gene transfer in a variety of model organisms, including plants, fruit flies, and even worms. If they're really interested in patterns of inheritance in humans, why don't they use humans or at least larger animals more similar to humans, such as pigs or even primates?

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Often geneticists want to change one allele in an outcrossing organism while keeping the rest of the genome the same. For example, they might wish to take a specially designed stock of flies and alter the eye color from red to white. Suppose that the white-eye allele is dominant, meaning that flies with one or two white-eye alleles will have white eyes. One procedure used is to take a white-eyed fly and cross it with the red-eyed stock. The whiteeyed offspring are then considered to be the first generation, and are crossed with the red-eyed stock. Their white-eyed offspring are considered to be the second generation, and are again crossed with the red-eyed stock, and so forth. The special red-eyed stock is homozygous for the desirable allele A at some other locus, but the white-eyed fly is homozygous for the inferior a allele at that locus. What is the genotype at the eye color locus in the second and subsequent generations?
You are working in the lab with strains of Drosophila that have either normal legs or abnormally short legs and you are studying the gene responsible. You know that normal legs are dominant to short legs. You come across a misplaced fly with normal legs, but you are not sure of his genetic background and you want to keep him in your experiments. (Without doing a molecular analysis), How could you figure out whether he was heterozygous or homozygous for the leg gene that you are studying? (Describe what you would do and how the results would answer the question.) What is the procedure you described above called?
Often geneticists want to change one allele in an outcrossing organism while keeping the rest of the genome the same. For example, they might wish to take a specially designed stock of flies and alter the eye color from red to white. Suppose that the white-eye allele is dominant, meaning that flies with one or two white-eye alleles will have white eyes. One procedure used is to take a white-eyed fly and cross it with the red-eyed stock. The whiteeyed offspring are then considered to be the first generation, and are crossed with the red-eyed stock. Their white-eyed offspring are considered to be the second generation, and are again crossed with the red-eyed stock, and so forth. The special red-eyed stock is homozygous for the desirable allele A at some other locus, but the white-eyed fly is homozygous for the inferior a allele at that locus. What fraction of flies will have the a allele (at the second locus) after t generations?
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY