Concept explainers
(a)
To determine: The maintenance and establishment of high concentration of Binding protein (BiP) in the lumen of endoplasmic reticulum and lesser concentrations in other regions of the cells.
Introduction: Protein folding is a process where folding of the polypeptide chain to form a 3D structure of protein takes place. Many different types of molecular interactions are involved in the process.
(b)
To determine: The effect on the cell if the gene encoding BiP acquires a mutation that disrupts the protein binding site for hydrophobic amino acids.
Introduction: Protein folding is a process where folding of the polypeptide chain to form a 3D structure of protein takes place. Many different types of molecular interactions are involved in the process.
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Becker's World of the Cell (9th Edition)
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