Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 18, Problem 3RQ
Summary Introduction

To determine: The four factors which regulate the amount of oxygen that binds to hemoglobin.

Introduction: The blood contains protein hemoglobin, which carries oxygen to the body parts. The hemoglobin carries more than 98% of the oxygen.

Summary Introduction

To determine: The most important factor which regulates the amount of oxygen that binds to hemoglobin.

Introduction: The blood contains protein hemoglobin, which carries oxygen to the body parts. The oxygen binds to the hemoglobin and is carried to the tissues and organs of the body. The hemoglobin carries more than 98% of the oxygen.

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In the text, we learned that BPG is abundantly present in erythrocytes to greatly reduce the affinity of hemoglobin for oxygen. When 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. What would happen to hemoglobin if the BPG were removed? Would our body still be able to efficiently deliver oxygen to the tissues?
What is the critical amino acid difference between the beta-chain and the gamma-chain of hemoglobin? How does this difference affect the hemoglobin binding to oxygen?
In addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.

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Human Physiology: An Integrated Approach (8th Edition)

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