Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 18, Problem 30RQ
Summary Introduction
To determine: The fate of the oxygen-hemoglobin saturation curve with reference to the figure 18.9a given in the textbook.
Introduction: The oxygen-hemoglobin saturation curve represents the relationship between the saturation of the hemoglobin molecule in percent with respect to the pressure of oxygen.
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Select the hemoglobin variant(s) that are described by each statement.
(a) The variant least likely to cause pathological symptoms.
(b) The variant(s) likely to show pl values different from that of HbA on an isoelectric
focusing gel.
(c) The variant most likely to show a decrease in BPG binding and an increase in
the overall affinity of the hemoglobin for oxygen.
Answer Bank
Hb Milwaukee
Hb Cowtown
Hb Memphis
Hb Philly
Hb Providence
Hb Bibba
HbS
Considering the quantity of hemoglobin in an erythrocyte and the oxygen-binding properties of hemoglobin, calculate how many molecules of oxygen one erythrocyte could carry?
Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m),and you begin to ponder the “big questions,” such as “What is the fractionalsaturation of the Dalai Lama’s hemoglobin?”(a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2,and a P50 = 31 mm Hg, calculate the change in fractional O2 saturationof his hemoglobin going from his lungs (where PO2 = 85 mm Hg) to hiscapillaries (where PO2 = 25 mm Hg).(b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher thannormal (where “normal” = 27 mm Hg)?
Chapter 18 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 18.1 - Cellular metabolism review: which of the following...Ch. 18.1 - Why doesnt the movement of oxygen from the alveoli...Ch. 18.1 - If nitrogen is 78% of atmospheric air, what is the...Ch. 18.1 - At the summit of Mt. Everest, an altitude of 8850...Ch. 18.1 - Prob. 5CCCh. 18.1 - If alveolar ventilation increases, what happens to...Ch. 18.1 - True or false? Plasma with a PO2 of 40 mm Hg and a...Ch. 18.1 - A saline solution is exposed to a mixture of...Ch. 18.2 - Can a person breathing 100% oxygen at sea level...Ch. 18.2 - What effect does hyperventilation have on the...
Ch. 18.2 - A muscle that is actively contracting may have a...Ch. 18.2 - How would an obstruction of the airways affect...Ch. 18 - List five factors that influence the diffusion of...Ch. 18 - Prob. 2RQCh. 18 - Prob. 3RQCh. 18 - Describe the structure of a hemoglobin molecule....Ch. 18 - Prob. 5RQCh. 18 - Describe the chemoreceptors that influence...Ch. 18 - Describe the protective reflexes of the...Ch. 18 - What causes the exchange of oxygen and carbon...Ch. 18 - List five possible physical changes that could...Ch. 18 - Concept map: Construct a map of gas transport...Ch. 18 - Prob. 11RQCh. 18 - Prob. 12RQCh. 18 - Prob. 13RQCh. 18 - Define hypoxia, COPD, and hypercapnia.Ch. 18 - Why did oxygen-transporting molecules evolve in...Ch. 18 - Draw and label the following graphs: a. the effect...Ch. 18 - Prob. 17RQCh. 18 - Prob. 18RQCh. 18 - Create reflex pathways (stimulus, receptor,...Ch. 18 - Prob. 20RQCh. 18 - Which person carries more oxygen in his blood? a....Ch. 18 - What would happen to each of the following...Ch. 18 - In early research on the control of rhythmic...Ch. 18 - Prob. 24RQCh. 18 - Prob. 25RQCh. 18 - Prob. 26RQCh. 18 - Prob. 27RQCh. 18 - Prob. 28RQCh. 18 - Adolph Fick, the nineteenth-century physiologist...Ch. 18 - Prob. 30RQ
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- What is oxyhemoglobin? Where does it form?arrow_forwardBelow is a fractional saturation curve for O₂ binding to adult hemoglobin. Assume that curve Y represents a condition at pH 7.4 and with a normal physiological level of 2,3-BPG. Curve X represents a condition that Fractional saturation (0) 0.2 0.0 0 Tissue PO, (kPa) 12 Lungsarrow_forwardAfter spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?arrow_forward
- Suppose Gina climbs a high mountain where the oxygen partial pressure in the air decreases to 70 torr. Assume that the pH of her tissues and lungs is 7.4 and the oxygen concentration in her tissues is 20 torr. The P50 of hemoglobin is 26 torr. The degree of cooperativity of hemoglobin, n, is 2.8. Estimate the percentage of the oxygen-carrying capacity that she utilizes. Calculate your answer to one decimal place. сараcity: %arrow_forwardBelow is an oxygen-binding curve for two hemoglobin variants. 1.0 0.8 0.6 B 0.4 0.2 20 40 60 80 100 O2 pressure (torr) Determine the p50 for variant A to the nearest 5 torr (i.e., if the p50 was 12, you would write 10). Determine the fraction of the hemoglobin B bound with O2 in the lungs (pO2 = 100 torr) that delivers oxygen to the tissues (pO2 = 20 torr)? Answer to the nearest 0.05 value (for example, 0.10 or 0.15). Which hemoglobin variant (write A or B or same) delivers more oxygen to tissues? Fraction bound with O2arrow_forwardIn the text, we learned that BPG is abundantly present in erythrocytes to greatly reduce the affinity of hemoglobin for oxygen. When 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. What would happen to hemoglobin if the BPG were removed? Would our body still be able to efficiently deliver oxygen to the tissues?arrow_forward
- A patient carrying a mutant form of hemoglobin (KD = 48 torr) is planning to take part in a hiking trip that involves strenuous physical activity at ~10,000 feet above sea level. The mutant hemoglobin has reduced oxygen binding cooperativity (n = 2.2) and displays no major structural abnormalities. a. Calculate the percent saturation of hemoglobin in the lungs (pO2 = 70 torr at this elevation) for this patient and for an individual carrying a normal version of hemoglobin b. Calculate the percent saturation of hemoglobin in active skeletal muscle tissue (pO2 = 15 torr) for this patient and for an individual carrying a normal version of hemoglobin c. Will this patient transport oxygen from the lungs to active muscle tissues more or less efficientlythan an individual with a normal version of hemoglobin on this trip? Briefly explain your answerarrow_forwardSuppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m), and you begin to ponder the “big questions,” such as “What is the fractional saturation of the Dalai Lama’s hemoglobin?” a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2, and a P50 = 31 mmHg, calculate the change in fractional O2 saturation of his hemoglobin going from his lungs (where PO2 = 85 mmHg) to his capillaries (where PO2 = 25 mmHg). b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher than normal (where “normal” = 27 mmHg)?arrow_forwardBelow is the equation that represents O2 binding to hemoglobin. Hb+4O2⇌Hb(O2)According to Le Chatelier’s principle, which form of the hemoglobin (Hb or Hb(O2)4) is predominant in the lungs where the partial pressure of oxygen is high? Explain. I need help answering thisarrow_forward
- 2,3-bisphosphoglycerate (BPG) is a negative allosteric regulator of hemoglobin that is produced in red blood cells. Normally, red blood cell levels of BPG are 5 mmol/L, yielding curve 2. Individuals acclimated to high altitudes can have BPG levels of 8 mmol/L to optimize their oxygen utilization. Saturation 2 3 S Which curve represents hemoglobin of someone living at normal altitudes? 1 2 Pos (mm Hg) 3 None of the answers are correct 2 and 3arrow_forwardName 3 conditions (ex: pO2) in which the oxygen dissociation curve will shift to the left. Additionally, when there is such a shift to the left, does that mean that hemoglobin's affinity for O2 has increased or decreased?arrow_forwardFigure 5 shows oxyhemoglobin dissociatlon curves at pH 7.2 and pH 7.4. Which of the following is true at PO2 less than 40 mm Hg? 27. % saturation af haemogiobin 100 pH 7.4 80 60 pH 7.2 40 + 20 10 20 30 40 50 60 70 Po; (mm Hg) Figure 5 A. Hemoglobin retains less O2 at pH 7.4 compared to pH 7.2. B. Hemoglobin retains less O2 at pH 7.2 compared to pH 7.4. C. The release of O2 from hemoglobin is not influenced by the production of CO2. D. At pH 7.2 where CO2 production is less than pH 7.4, hemoglobin releases less O2.arrow_forward
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