Biology: Concepts and Investigations
5th Edition
ISBN: 9781260259049
Author: Hoefnagels
Publisher: MCG
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Chapter 17, Problem 3WIO
If you were developing a new "broad-spectrum" antibiotic to kill a wide variety of bacteria, which cell structures and pathways would you target? Which of those targets also occur in eukaryotic cells, and why is that important? How would your strategy change if you were designing a new "narrow-spectrum" antibiotic active against only a few types of bacteria?
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Chapter 17 Solutions
Biology: Concepts and Investigations
Ch. 17.1 - What are two domains that contain prokaryotes?Ch. 17.1 - Prob. 2MCCh. 17.1 - Prob. 3MCCh. 17.1 - Prob. 4MCCh. 17.2 - Prob. 1MCCh. 17.2 - Prob. 2MCCh. 17.2 - What does the Gram stain reveal about a cell?Ch. 17.2 - Prob. 4MCCh. 17.2 - Prob. 5MCCh. 17.2 - How are molecular data changing microbial...
Ch. 17.2 - Prob. 7MCCh. 17.3 - Prob. 1MCCh. 17.3 - Prob. 2MCCh. 17.3 - Prob. 3MCCh. 17.4 - Prob. 1MCCh. 17.4 - Prob. 2MCCh. 17.4 - What adaptations enable pathogenic bacteria to...Ch. 17.4 - What are some practical uses of bacteria and...Ch. 17.5 - Prob. 1MCCh. 17.5 - Prob. 2MCCh. 17 - A prokaryotic cell is one that a. lacks DNA. b....Ch. 17 - Which of these is a distinguishing characteristic...Ch. 17 - What feature distinguishes the cell walls of...Ch. 17 - Prob. 4MCQCh. 17 - Prob. 5MCQCh. 17 - Prob. 6MCQCh. 17 - Prob. 7MCQCh. 17 - Prob. 8MCQCh. 17 - Explain why the antibiotics penicillin and...Ch. 17 - Give five examples that illustrate how bacteria...Ch. 17 - If you were developing a new "broad-spectrum"...Ch. 17 - Ernst Mayr defined a biological species as a...Ch. 17 - In an article in Nature magazine, Sean Nee wrote...Ch. 17 - Ecosystems rely on nitrogen -fixing bacteria,...Ch. 17 - Prob. 7WIOCh. 17 - Prob. 8WIOCh. 17 - Prob. 9WIOCh. 17 - Prob. 10WIOCh. 17 - Mycobacterium tuberculosis causes most cases of...Ch. 17 - Prob. 1PITCh. 17 - Add autotrophs, heterotrophs, phototrophs, and...Ch. 17 - Prob. 3PITCh. 17 - Prob. 4PITCh. 17 - Prob. 5PIT
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The ribosome is the target for many important antibiotics. These drugs must discriminate between bacterial and eukaryotic ribosomes to achieve drug specificity and toxicity. For the two common antibiotics below, what is their mechanism of action and why are they more toxic to bacteria than eukaryotes? a) Tetracycline b) Erythromycinarrow_forwardIntroduction: There’s quite a bit of interest around repurposing extant drugs to treat infections by targeting host pathways that pathogens rely on. Here are a few potential drugs: 1) A drug that inhibits endocytosis, but not phagocytosis. 2) A drug that inhibits degradation of cytoplasmic proteins into smaller peptides, preventing their cycling back into amino acids. 3) A drug used to treat porphyria that reduces the reactivity of heme. 4) A drug that depletes glutathione, a chemical which protects red blood cells against the reactivity of heme. 5) A drug that reduces expression of the ACE-2 protein. Question: Pick a drug and an infection that the drug is likely to be good at treating, or pick an infection and a drug that would most likely make the infection substantially worse. Which drug and pathogen did you pick? Do you think it’ll make it better or worse?arrow_forwardSoil bacteria such as Streptomyces spp. produce the bulk of known antibiotics. It has been suggested that in nature antibiotics serve as signaling molecules, allowing members of the same species or strain to communicate. If this is the case, what might these molecular signals be “saying” and how would such a message be transmitted?arrow_forward
- Usually, bacteria only make tryptophan when tryptophan is absent or available in low concentration. However, a particular bacterial mutation makes tryptophan all the time whether or not tryptophan is present. What could explain this phenotype? A) the terminator hairpin is unable to form B) the antiterminator hairpin is unable to form C) trpE is mutated D) trpD is mutated E) trpA is mutatedarrow_forwardAntibiotic resistant bacteria have become a major concern for many public health officials. Widespread use of antibiotics has created an evolutionary pressure on infectious bacteria to develop immunity to these medications. The result is an increase in antibiotic resistant microbes, particularly in settings where antibiotics are commonly used, such as hospitals. One strategy public health officials have devised to counteract these infectious microbes is "antibiotic cycling” where specific antibiotics are withdrawn from the market for a period of several years, then reintroduced as another antibiotic is withdrawn. How would this strategy help limit antibiotic resistance? A. It is impossible for a bacterium to maintain resistance to two antibiotics at once B. When a given antibiotic is not in use, it is an evolutionary disadvantage to carry the unneeded gene C. If a specific antibiotic is removed from the market it is possible to substitute with a related antibiotic such as…arrow_forwardResults from a Kirby Bauer antibiotic assay on a Gram-negative bacterial culture are described as follows: A) the bacterium is resistant to penicillin, an antibiotic that targets synthesis of the peptidoglycan cell wall and B) the bacterium is resistant to tetracycline, an antibiotic that targets the small subunit of the ribosome, inhibiting protein synthesis. Which of the results represents intrinsic resistant and which represents acquired resistants?arrow_forward
- Most antibacterial drugs disrupt or destroy prokaryotic cellular structures or processes that are different than those of eukaryotic cells or may not even be present in eukaryotic cells. List and describe at least three prokaryotic cellular features that could be targeted to inhibit or kill a bacterial pathogen without harming its eukaryotic host.arrow_forwardWhich statement among A-D is false regarding bacterial toxins? A) O Hemolysıns are cell membrane disrupters that can rupture red blood cells. B) O Second mesengar pathway disrupters like cholera toxin produces a debilitating respiratory condition of the lungs. C) O Shiga toxin, tetanus toxin, and hemolysins are all types of exotoxins. D) O Superantigens elicit a hyperactive response by the immune system and can lead to shock. E) O None are false, A-D are all true statements.arrow_forwardFor a bacterial exotoxin with a typical A-B type toxin structure, removal of the A portion of the toxin would result in which of the following? The B portion remaining would still be able to bind to the target cell, but would not have toxic effects The remaining B portion would enter the cell and carry out its toxic activity, such as ADP-ribosylation The remaining B portion would cause inhibition of protein synthesis Nothing would happen because the A portion is responsible for binding to the target cell. The remaining B portion would still induce cell lysis Please answer asap and in short and content should not be palgarised pleasearrow_forward
- Which of the following models best depicts how the genetic information in a retrovirus is eventually translated into proteins? A) DNA in the retrovirus → RNA in the host cell → Proteins B) RNA in the retrovirus → DNA in the host cell → RNA in the host cell → Proteins C) RNA in the retrovirus → mRNA in the host cell → Proteins D) DNA in the retrovirus → mRNA in the host cell → Proteinsarrow_forwardIn their Nobel Prize-winning experiments, Beadle and Tatum exposed fungal spores to X-rays to induce mutations. If the mutants had mutations in the arginine metabolic pathway, they would grow in ------minimal medium (wrong answer), but NOT in -------complete medium (wrong answer).arrow_forward25) Identify the most correct choice: a) ribosomes are the membrane bound organelles responsible for making proteins from RNAs. b) In gene therapy, Agrobacterium is the bacteria that transfers genetic material into the human cells that contain the mutated gene. c) spectrophotometer analysis can be used to detect the concentration of the dead cells in a solution only and not those that are living. d) None of the above.arrow_forward
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