Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 17, Problem 11QP
It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the multiple steps and the ways in which the steps are connected to each other. Draw the antibody-mediated immune response pathway that acts in response to an invading virus.
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Students have asked these similar questions
Neutralizing antibodies are effective at preventing infection or toxicity mediated by pathogens or their toxic products. In fact, nearly all
vaccines currently in use function by eliciting neutralizing antibodies. One example is the tetanus vaccine, in which neutralizing
antibodies are generated against an inactivated form of the tetanus toxin (the tetanus toxoid). The most important feature of a
neutralizing antibody is
having high affinity for the antigen.
being efficient at activating the complement cascade.
having a high degree of multivalency, such as being a pentamer or hexamer of immunoglobulin monomers.
being present at a high concentration in the circulation.
0 0 0 0
Experiments are performed to analyze protein tyrosine phosphorylation in response to TCR stimulation. For these experiments, T cells are stimulated with anti-CD3 antibody, and then lysates are prepared and run on a protein (SDS-PAGE) gel to separate the proteins by molecular weight. The proteins are transferred from the gel to a membrane for immunoblotting using an antibody that binds to all phosphorylated tyrosine residues in any protein; this antibody is called ‘anti-phospho-tyrosine antibody,’ and is abbreviated as anti-P-Y. The results are shown in the figure below. You confirm that the mutant T cells express normal levels of all the proteins detected in the WT cells, including PLC-g, SLP-76, ITK, ZAP-70, LCK, LAT, and the CD3 and TCRz proteins.
Based on these data, which of the following proteins (biotin, hygromycin, and streptavidin) can rule out its presence? Briefly explain your answer.
What protein is most likely defective in the mutant cells and why?
For the protein you…
In the antibody-mediated immune response, the binding of some antigen-presenting B
cells to helper T cells initiates a signal transduction pathway that transforms the B cells into
plasma cells, which will synthesize and secrete large quantities of antibodies-a specialized
subset of proteins responsible for attaching to the antigen on the outer surface of
pathogens.
Which of the following describes the most relevant intracellular change to B cells as they
are transformed into plasma cells?
A
B
a breakdown of some membrane-bound proteins to allow synthesized antibodies to
more readily diffuse across the membrane of the plasma cell
с
an increase in the surface area of the rough endoplasmic reticulum in order to allow the
binding of a large number of ribosomes for antibody synthesis
D
an increase in the number of lysosomes in order to facilitate the storage of synthesized
antibodies ahead of their transport out of the cell
an increase in the volume of the mitochondria in order to increase…
Chapter 17 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 17.8 - One treatment for peanut allergies is to give an...Ch. 17.8 - Prob. 2EGCh. 17 - Prob. 1CSCh. 17 - The Joneses were referred to a clinical geneticist...Ch. 17 - The Inflammatory Response Is a General a. What...Ch. 17 - The Complement System Kills Microorganisms The...Ch. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 4QPCh. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 6QP
Ch. 17 - Prob. 7QPCh. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 9QPCh. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - It is often helpful to draw a complicated pathway...Ch. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 14QPCh. 17 - Prob. 15QPCh. 17 - Blood Types Are Determined by Cell-Surface...Ch. 17 - Prob. 17QPCh. 17 - Blood Types Are Determined by Cell-Surface...Ch. 17 - Prob. 19QPCh. 17 - Prob. 20QPCh. 17 - Prob. 21QPCh. 17 - Organ Transplants Must Be Immunologically A burn...Ch. 17 - Organ Transplants Must Be Immunologically In the...Ch. 17 - Organ Transplants Must Be Immunologically In the...Ch. 17 - Organ Transplants Must Be Immunologically A couple...Ch. 17 - Prob. 26QPCh. 17 - Disorders of the Immune System Antihistamines are...Ch. 17 - Disorders of the Immune System Autoimmune...Ch. 17 - Prob. 29QPCh. 17 - Prob. 30QPCh. 17 - Prob. 31QP
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- Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.arrow_forwardc) State some of the features that cross the cell membrane and make "porin proteins" specific. d) Briefly clarify the concepts of "acylation", "prenylation" and "GPI stabilizer" in the context of membrane protein interactions. e) When determining ABO Blood Groups, give information about which blood group data can be obtained depending on the interaction of which antigens in the red blood cell and which antibodies in the serum.arrow_forwardSomatic cells can display antigen [small peptides] and present them to the body’s immunesystem via their MHC/HLA receptor displays. Discuss the paths for MHC/HLA1 vs. MHC/HLA2display. How do these two paths fit into the health of the body, and the response of theimmune system to normal/disease/infection?arrow_forward
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