Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because:Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces.When the complement cascade leads to the formation of a membrane-attack complex, the pathogen is killed.Several of the soluble products generated by complement activation lead promote the inflammatory response.Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells.The C3 convertase is only produced when complement activation is initiated by antibody binding to a pathogen.

BASIC INFORMATION IMMUNE SYSTEM It defends our body from the foreign particles which can cause harm…

Answered: Although the complement cascade can be…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 14RE

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Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because:

Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces.
When the complement cascade leads to the formation of a membrane-attack complex, the pathogen is killed.
Several of the soluble products generated by complement activation lead promote the inflammatory response.
Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells.
The C3 convertase is only produced when complement activation is initiated by antibody binding to a pathogen.

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